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Master's Thesis from the year 2016 in the subject Medicine - Epidemiology, grade: 70, University of Zambia, language: English, abstract: The objective of this study was to determine the risk associated with the use of PIs- containing ART in the development of CVD among HIV seropositive adult's at the Adult Infectious Disease Centre University Teaching Hospital (UTH), Zambia.The burden of cardiovascular disease (CVD) in Sub-Saharan Africa is rising in the background of a high prevalence of infectious diseases including Human Immune Deficiency Virus (HIV). The use of certain Antiretroviral Therapy (ART) drugs has been shown to cause dyslipidaemia, with little known about the burden of dyslipidaemia in the presence of ART particularly Protease Inhibitors (PIs) in Sub-Saharan Africa.The study reviewed records of patients on PIs and non- PIs between 2008 and 2016. The primary end point of the study was CVD and consisted of a total sample of 281, with PI consisting of 112 and 169 for the non PI group. A log-binomial model was used to assess covariates, while Kaplan Meier method for probability of survival to CVD and time to CVD comorbidity were utilised.