Andere Kunden interessierten sich auch für
![The Role of GABP-a/b In the Proliferation of NIH-3T3 Cells]( "The Role of GABP-a/b In the Proliferation of NIH-3T3 Cells")
The Role of GABP-a/b In the Proliferation of NIH-3T3 Cells45,99 €![Role of neuronal IGF-1R signaling in Alzheimer¿s disease]( "Role of neuronal IGF-1R signaling in Alzheimer¿s disease")
Role of neuronal IGF-1R signaling in Alzheimer¿s disease35,99 €![The role of leptin in cardiovascular diseases]( "The role of leptin in cardiovascular diseases")
The role of leptin in cardiovascular diseases46,99 €![The Role of HIV Genetic Pathway in Apoptosis]( "The Role of HIV Genetic Pathway in Apoptosis")
The Role of HIV Genetic Pathway in Apoptosis42,99 €![Role of aberrations in folate pathway in the etiology of breast cancer]( "Role of aberrations in folate pathway in the etiology of breast cancer")
Role of aberrations in folate pathway in the etiology of breast cancer46,99 €![Role of Notch Pathway in the pathogenesis of T- ALL]( "Role of Notch Pathway in the pathogenesis of T- ALL")
Role of Notch Pathway in the pathogenesis of T- ALL48,99 €![The role of the Hr gene in brain, gut and thymus development in the mouse]( "The role of the Hr gene in brain, gut and thymus development in the mouse")
The role of the Hr gene in brain, gut and thymus development in the mouse32,99 €
Identification of novel tumour-specific genes and pathways is a key strategy to gain additional prognostic markers and to identify molecular targets for chemical and/or immunological therapy. The combination of subtractive cDNA libraries and cDNA microarrays lead to the identification of the human calcium-activated chloride channel 2 (CLCA2), a member of the family of calcium-activated cytoplasmic trans-membrane chloride channel proteins. CLCA2 is highly expressed in lung squamous cell carcinoma. In the course of this PhD-Thesis a preferential overexpression of CLCA2 was shown in human squamous cell carcinomas (SCC) of different origins. CLCA2 was confirmed as a promising target in SCC tumourigenesis by in silico analysis of expression data, loss-of-function studies in SCC cell lines by siRNA-mediated knock-down, preliminary IHC analyses, inducible expression in tumour cells in combination with a detailed mutational analysis, 3D-In vitro carcinoma assays in multicellular tumour spheroids, expression profiling studies on Affymetrix GeneChips, and by utilising a text- and data-mining program for identification of several interaction-networks.