Shihab Mahmood, Raad Alasady, Fadhil Al-Muhannak

The Role of Galectin-3 and Interleukin-22

In The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis

• Broschiertes Buch

Produktbeschreibung

Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease that primarily affects small joints. While there are currently established biomarkers that can be used to diagnose RA, such as RF and ACPA, there is still a need for new biomarkers to improve the accuracy and early detection of RA because it is a complex and heterogeneous disease, with a wide range of symptoms and disease courses. This research aimed to study the diagnostic value of galectin-3 and interleukin-22 as ideal biomarkers for the diagnosis of RA , in addition to study their roles in the evaluation of RA activity. Levels of gal-3 and IL-22 were positively correlated with the disease activity indices CDAI, DAS-28 ESR, and DAS-28 CRP. Regarding the diagnostic values of gal-3 and IL-22 in the detection of RA, receiver operating characteristic (ROC) curves revealed that the best diagnostic cut-off value of urinary gal-3 was 2.4 ng/ml, with 89% sensitivity, 91% specificity, and an area under the curve (AUC) = 0. 893. While the best diagnostic cut-off value of IL-22 was 26.9 pg/ml, with 83% sensitivity, 75% specificity, and an area under the curve (AUC) = 0.838.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 196
• Erscheinungstermin: 17. November 2023
• Englisch
• Abmessung: 220mm x 150mm x 12mm
• Gewicht: 310g
• ISBN-13: 9786206845782
• ISBN-10: 6206845788
• Artikelnr.: 69624326

Autorenporträt

Sono un microbiologo/immunologo, Direzione sanitaria di Al-Najaf, Iraq. B.Sc. Analisi Patologica / College of Health and Medical Techniques / Università di Alkafeel con un master in Microbiologia Medica presso il Dipartimento di Microbiologia, College of Medicine, Università di Kufa.