Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.
Foreword. Preface. Acknowledgements. Part I: NO and Pathophysiology of Heart Failure. Nitric Oxide in Heart Failure: Friend or Foe; B.I. Jugdutt. NO and the Vasculature: Where Does It Come from and What Does It Do? K.L. Andrews, C.R. Triggle, A. Ellis. Myocardial Contractile Effects of Nitric Oxide Walter; J. Paulus, J.G.F. Bronzwaer. Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies; D. Alonso, M.W. Radomski. Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction; T.J. Anderson. Regulation of Cardiac Remodeling by Nitric Oxide: Focus on Cardiac Myocyte Hypertrophy and Apoptosis; K.C. Wollert, H. Drexler. Role of Nitric Oxide in the Pathophysiology of Heart Failure; H.C. Champion, M.W. Skaf, J.M. Hare. Nitric Oxide, Cell Death, and Heart Failure; J.-i. Oyama, S. Frantz, C. Blais, R.A. Kelly, T. Bourcier. Acute and Chronic Endothelial Dysfunction: Implications for the Development of Heart Failure; A. Linke, F. Recchia, Xiaoping Zhang, T.H. Hintze. The Role of NOS in Heart Failure: Lessons from Murine Genetic Models; I.N. Mungrue, M. Husain, D.J. Stewart. Part II: NO and Cardiovascular Therapeutics. Nitric Oxide and Cardiovascular Protection; B.I. Jugdutt. Angiotensin II and Nitric Oxide Interaction; M. de Gasparo. The Nitric Oxide-Endothelin-1 Connection; D. Alonso, M.W. Radomski. The Therapeutic Effect of Natriuretic Peptides in Heart Failure; Differential Regulation of Endothelial and Inducible Nitric Oxide Synthases; A. Calderone. Mechanisms Underlying Nitrate-Induced Endothelial Dysfunction: Insight from Experimental and Clinical Studies; A. Warnholtz, N. Tsilimingas, M. Wendt, T.H. Hintze. Statins and the Role of Nitric Oxide in Chronic Heart Failure; S. von Haehling, S.D. Ankel, E. Bassenge. Role of Nitric Oxide in Matrix Remodeling in Diabetes and Heart Failure; S.C. Yagi, M.R. Hayden. Peroxynitrite in Myocardial Ischemia-Reperfusion Injury; M.M. Lalu, Wenjie Wang, R. Schulz. The Role of the NO Axis and its Therapeutic Implications in Pulmonary Arterial Hypertension; E.D. Michelakis. Nitric Oxide and Cardioprotection During Ischemia-Reperfusion; B.I. Jugdutt. Index.
Foreword. Preface. Acknowledgements. Part I: NO and Pathophysiology of Heart Failure. Nitric Oxide in Heart Failure: Friend or Foe; B.I. Jugdutt. NO and the Vasculature: Where Does It Come from and What Does It Do? K.L. Andrews, C.R. Triggle, A. Ellis. Myocardial Contractile Effects of Nitric Oxide Walter; J. Paulus, J.G.F. Bronzwaer. Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies; D. Alonso, M.W. Radomski. Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction; T.J. Anderson. Regulation of Cardiac Remodeling by Nitric Oxide: Focus on Cardiac Myocyte Hypertrophy and Apoptosis; K.C. Wollert, H. Drexler. Role of Nitric Oxide in the Pathophysiology of Heart Failure; H.C. Champion, M.W. Skaf, J.M. Hare. Nitric Oxide, Cell Death, and Heart Failure; J.-i. Oyama, S. Frantz, C. Blais, R.A. Kelly, T. Bourcier. Acute and Chronic Endothelial Dysfunction: Implications for the Development of Heart Failure; A. Linke, F. Recchia, Xiaoping Zhang, T.H. Hintze. The Role of NOS in Heart Failure: Lessons from Murine Genetic Models; I.N. Mungrue, M. Husain, D.J. Stewart. Part II: NO and Cardiovascular Therapeutics. Nitric Oxide and Cardiovascular Protection; B.I. Jugdutt. Angiotensin II and Nitric Oxide Interaction; M. de Gasparo. The Nitric Oxide-Endothelin-1 Connection; D. Alonso, M.W. Radomski. The Therapeutic Effect of Natriuretic Peptides in Heart Failure; Differential Regulation of Endothelial and Inducible Nitric Oxide Synthases; A. Calderone. Mechanisms Underlying Nitrate-Induced Endothelial Dysfunction: Insight from Experimental and Clinical Studies; A. Warnholtz, N. Tsilimingas, M. Wendt, T.H. Hintze. Statins and the Role of Nitric Oxide in Chronic Heart Failure; S. von Haehling, S.D. Ankel, E. Bassenge. Role of Nitric Oxide in Matrix Remodeling in Diabetes and Heart Failure; S.C. Yagi, M.R. Hayden. Peroxynitrite in Myocardial Ischemia-Reperfusion Injury; M.M. Lalu, Wenjie Wang, R. Schulz. The Role of the NO Axis and its Therapeutic Implications in Pulmonary Arterial Hypertension; E.D. Michelakis. Nitric Oxide and Cardioprotection During Ischemia-Reperfusion; B.I. Jugdutt. Index.
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