Spontaneous and induced cytotoxicity were observed from sea star axial organ against Mouse MBL2 and SP2 tumoral cells .These data were written in the years 1980 in the journal : »Immunology Letters » (Luquet G. and Leclerc M.)In this book, we mention more recent data, concerning : Spontaneous cytotoxicity from sea star Igkappa gene after cloning a) either cloning in CMV plasmidb)or in HeK human cellsThe targets being tumoral human cells :-Hela cells-A375 melanome cellsand other types of cancerous human cells