The year is 1835, only twenty years after the war of 1812. The methods of war and medicine are crude compared to the standards of today. The United States is a new and struggling country, ill-prepared for a virulent outbreak that aggressively sweeps through the young nation, ravaging all in its path. Inadvertently created by a brilliant doctor at the edge of the western frontier, while researching Native Indian tribe medicines in an effort to save the lives of his family. Across a barely tamed America, where steamships and horseback are the fastest ways to travel, divergent people and bands of defenders come together to combat an enigma beyond their understanding. striving to outrun an enemy sweeping through the countryside, they must create new methods to find something, anything to stop the madness. How will our heroes be able to put aside differences, adapt and rise to the occasion? Can this young and struggling nation face down this macabre new threat? Will groundbreaking technologies turn the tide and contain the horror of these dead-like enemies?