A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving…mehr
A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.
Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis Rocky S. Tuan
Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka
Regulation of Chondrocyte Differentiation Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe
Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty
Molecular Biology and Biosynthesis of Collagens Johanna Myllyharju
Mechanotransduction Pathways in Cartilage Qian Chen
II. Control of Skeletal Development
Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex Marie Kmita, Denis Duboule, and József Zßkßny
Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling Renee Hackenmiller, Catherine Degnin, and Jan Christian
FGF4 and Skeletal Morphogenesis Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka
Retinoid Signaling and Skeletal Development Andrea D. Weston and T. Michael Underhill
Retinoids and Indian Hedgehog Orchestrate Long Bone Development Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama
III. Osteoblastic Cell Differentiation
Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation John C. Lee and Lee-Chuan C. Yeh
Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis Rocky S. Tuan
Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka
Regulation of Chondrocyte Differentiation Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe
Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty
Molecular Biology and Biosynthesis of Collagens Johanna Myllyharju
Mechanotransduction Pathways in Cartilage Qian Chen
II. Control of Skeletal Development
Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex Marie Kmita, Denis Duboule, and József Zßkßny
Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling Renee Hackenmiller, Catherine Degnin, and Jan Christian
FGF4 and Skeletal Morphogenesis Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka
Retinoid Signaling and Skeletal Development Andrea D. Weston and T. Michael Underhill
Retinoids and Indian Hedgehog Orchestrate Long Bone Development Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama
III. Osteoblastic Cell Differentiation
Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation John C. Lee and Lee-Chuan C. Yeh
Bone Morphogenic Proteins,"
Rezensionen
"...a valuable book...Every substantial biomedical library should have this book." -Doody's Health Sciences Book Review Journal "Very detailed, clinical and laden with biological terminology, which makes the preface a must for new readers." -E-STREAMS "Authoritative and up-to-date... a cutting-edge survey of diverse critical issues in bone biology." - Clinical Laboratory International
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