The Third Histamine Receptor

Selective Ligands as Potential Therapeutic Agents in CNS Disorders
Herausgeber: Vohora, Divya

• Gebundenes Buch

Produktbeschreibung

Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development. The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer's, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 406
• Erscheinungstermin: 14. November 2008
• Englisch
• Abmessung: 236mm x 157mm x 25mm
• Gewicht: 676g
• ISBN-13: 9781420053920
• ISBN-10: 1420053922
• Artikelnr.: 22146485

Autorenporträt

Vohora, Divya

Inhaltsangabe

INTRODUCTION. H3 Receptor Target: Past, Present, and Future Perspectives
from Worldwide H3 Experts. The Third Histamine Receptor: From Discovery to
Clinics, a Long- Lasting Love Story at INSERM and Bioprojet. Histamine as a
Neurotransmitter. THE THIRD HISTAMINE RECEPTOR. Phylogeny, Gene Structure,
Expression, and Signaling. Drug Discovery: From Hits to Clinical
Candidates. Peripheral Actions and Therapeutic Potential in Periphery.
THERAPEUTIC POTENTIAL IN CENTRAL NERVOUS SYSTEM DISORDERS. Cognitive
Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer's
Disease. Sleep Disorders. Obesity. Epilepsy. Schizophrenia. Other Central
Nervous System Disorders.