Novartis Foundation

The Tumour Microenvironment

Causes and Consequences of Hypoxia and Acidity
Ed. by Derek J. Chadwick and Jamie A. Goode

• Gebundenes Buch

Produktbeschreibung

Ergebnisse von in vitro-Studien lassen vermuten, dass sich der pH-Wert in einem Tumor auf die Wirksamkeit von Chemo- oder Strahlentherapien auswirken kann. Wie aber sieht die Beziehung zwischen der Tumorentwicklung und dem pH-Wert aus? Können ein niedriger pH-Wert oder ein Sauerstoffmangel die Carcinogenese hemmen? Wo bieten sich therapeutische Ansätze? Anwort auf diese und andere Fragen finden Sie in diesem Band. In interdisziplinärer Weise wurden Beiträge aus der Grundlagenforschung und der klinischen Praxis zusammengetragen.
Several fundamentally important questions form the basis for this book. What are the relationships between tumour perfection and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH?
It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumourigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo and radiotherapy. By considering the consequences of, or manipulation of pH, more effective tharapies may be realised

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Produktdetails

• Novartis Foundation Symposium 240
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 312
• Erscheinungstermin: 28. November 2001
• Englisch
• Abmessung: 237mm x 158mm x 19mm
• Gewicht: 610g
• ISBN-13: 9780471499596
• ISBN-10: 0471499595
• Artikelnr.: 14003890

Autorenporträt

Jamie Goode is a British author with a PhD in plant biology, and a wine columnist of The Sunday Express. Goode also contributes to wine publications such as Harpers, The World of Fine Wine, Decanter, GrapesTALK and Sommelier Journal. Derek J. Chadwick is the editor of The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity, published by Wiley.

Inhaltsangabe

Introduction (Robert J Gillies).
Frontiers in the Measurement of Cell and Tissue pH (Robert J Gillies and
Ronald M Lynch).
The Physiological Environment in Cancer Vascularization, Invasion and
Metastasis (Zaver M Bhujwalla et al).
Why are Cancers Acidic? A Carrier-Mediated Diffusion Model for H+ Transport
in the Interstitial Fluid (J R Griffiths et al).
pH and Therapy of Human Cancers (Jeffrey L Evelhoch).
Mathematical Models of Tumour Invasion Mediated by Transformation-Induced
Alteration of Microenvironmental pH (Robert A Gatenby and Edward T
Gawlinski).
pH Regulation of Renal Gene Expression (Norman P Curthoys et al)).
Genetic Determinants that influence Hypoxia-Induced Apoptosis (Rodolfo M
Alarcon et al).
Genomic Instability in Cancer (Sara Rockwell et al).
pH, Hypoxia and Metastasis (R P Hill et al).
Modelling Tumour Acidity and Invasion (Steven D Webb et al).
pH, Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour
Growth (Jacques Pouyssé gur et al).
pH and Chemotherapy (Natarajan Raghunand).
The HIF Pathway: Implications for Patterns of Gene Expression in Cancer
(Charles C Wykoff et al).
pH and Multidrug Resistance (Paul D Roepe).
'The Metabolism of Tumours' 70 Years Later (Gregg L Semenza et al).
The Multiple Mechanisms of Multidrug Resistance and Cellular pH (Sanford
Simon).
Summing Up (Robert J Gillies).
Index of Contributors.
Subject Index.

Rezensionen

I read this book from A to Z and I really enjoyed it...makes youwish you had been there, but if you were not, you can always buythis book..." (NMR in Biomedicine, October 2002)
"...an excellent compilation of some specific and significantwork..." ( Pharmaceutical Research , Vol. 19, No. 10, October2002)