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Little is known about the uncommon, rare, and very rare genetic disorders in Iraq. The aim of this book is to report a study of the pattern of uncommon, rare and very rare genetic disorders observed by one pediatrician at single tertiary pediatric center during three-year period. During three-year period (2016-2018), 43 patients (29 males, 14 females) with uncommon, rare and very rare genetic disorders were observed by one pediatrician at one tertiary pediatric center. Their ages ranged from 5 days to 17 years. In this series, very rare genetic disorders in Iraq included the thirty six case of Cutis laxa type II (Debre type) in the world, the case number 104 in the world of Sanjad-Sakati-Richardson-Kirk syndrome, the case number 130 in the world of Townes Brocks syndrome, and the case number 170 in the world of Coffin Siris syndrome.