This research explores the complex world of bacterial infections in nephrology, highlighting the challenges posed by multi-resistant bacteria. Conducted at CHU Sahloul over 9 years (January 2012 - December 2020), the retrospective study scrutinizes bacterial strains isolated by the nephrology department. Of the 2851 isolates analyzed, the majority came from the inpatient unit (83%), followed by the CPD (9.2%) and HD (7.8%) units. Urinary tract infections were most frequent on the inpatient unit (74.6%), with bacteremia in second place (13%). This work highlights the urgent need for a thorough understanding of bacterial ecology and antimicrobial resistance to optimize the management of patients with chronic kidney disease.