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Non-alcoholic Fatty Liver disease is the one of most common liver disease in the world, which is defined as the accumulation of fat 5% of liver weight. Presentation of the disease ranges from Simple Steatosis to Non-alcoholic Steatohepatitis, which is a progressive form that may lead to fibrosis, cirrhosis and ultimately hepatocellular carcinoma. Nonalcoholic Fatty Liver Disease is not a single disease, diagnosed by non-invasive biomarkers, imaging techniques and liver biopsy; non-invasive serum markers have been used in the assessment of Non-alcoholic Steatohepatitis, ranging from hepatocyte apoptosis by-product cytokeratin-18 fragments, liver biochemical profile serum such as alanine aminotransferase, aspartate aminotransferase, and nonspecific markers of systemic inflammation, such as interleukin-6.