It is unclear, and really no longer relevant, whether the information explosion that we now contend with has been fostered by the growth of specialization and subspecialization in medicine, or vice versa. What is clear is that the two are mutually supportive and constitute what would be in endocrine parlance a short-loop positive feedback system. As a result, for most areas of medicine, even the subspecialist in that area has a problem in maintaining currency, the more general specialist has substan tial difficulty in doing so, and the generalist is tempted to abandon the effort altogether.…mehr
It is unclear, and really no longer relevant, whether the information explosion that we now contend with has been fostered by the growth of specialization and subspecialization in medicine, or vice versa. What is clear is that the two are mutually supportive and constitute what would be in endocrine parlance a short-loop positive feedback system. As a result, for most areas of medicine, even the subspecialist in that area has a problem in maintaining currency, the more general specialist has substan tial difficulty in doing so, and the generalist is tempted to abandon the effort altogether. Nevertheless, for all, both the internal pressures of conscience and self-esteem and the external pressures generated by peer review, recertifi cation, and subspecialty boards create the need for continuous self-educa tion. We are, therefore, in an era in which the means of dissemination of new information deserves as much creative attention as does its acquisition.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Neuroendocrinology.- 1.1. Introduction.- 1.2. Neural Regulation of Endocrine Function.- 1.3. Hormone-Nervous System Interactions.- 1.4. Releasing Factors.- 1.5. Neuroendocrine Disease.- 1.6. The Pineal Gland.- References.- 2 Anterior Pituitary.- 2.1. Introduction.- 2.2. Corticotropin and Melanocyte-Stimulating Peptides.- 2.3. Thyrotropin.- 2.4. Gonadotropins.- 2.5. Prolactin.- 2.6. Somatotropin.- References.- 3 The Thyroid.- 3.1. Introduction.- 3.2. Neuroendocrine Regulation of Thyroid Function.- 3.3. Thyroid Hormones.- 3.4. Clinical Aspects of Thyroidology.- 3.5. Miscellaneous Aspects of Thyroidology.- References.- 4 The Ovary.- 4.1. Introduction.- 4.2. Estrogen Secretion Rates.- 4.3. Regulation of Follicular Growth.- 4.4. The Postmenopausal Ovary.- 4.5. Idiopathic Hirsutism.- 4.6. Side Effects of Estrogen.- References.- 5 The Testis.- 5.1. Introduction.- 5.2. Intrauterine and Neonatal Function.- 5.3. Puberty.- 5.4. Adult Physiology.- 5.5. Adult Pathophysiology.- 5.6. Influence of Other Disease on Testicular Function.- 5.7. Conclusions.- References.- 6 The Adrenal Cortex.- 6.1. Introduction.- 6.2. Corticosteroid Biosynthesis.- 6.3. Mechanism of Action of ACTH.- 6.4. Diseases of the Adrenal Cortex.- References.- 7 Aldosterone and the Renin-Angiotensin System.- 7.1. Introduction.- 7.2. Increased Aldosterone Production.- 7.3. Normal Aldosterone Production-Low-Renin Hypertension.- 7.4. Reduced Aldosterone Production.- References.- 8 Catecholamines and the Sympathoadrenal System.- 8.1. Introduction.- 8.2. Familial Pheochromocytoma and Multiple Endocrine Adenomatosis (MEA).- 8.3. Clinical Assessment of the Functional State of the Adrenal Medulla and the Sympathetic Nervous System.- 8.4. Hyperthyroidism and the Sympathoadrenal System.- References.- 9 Calcitonin.- 9.1.Introduction.- 9.2. Calcitonin.- References.- 10 Ectopic Hormone Syndromes.- 10.1. Introduction.- 10.2. Etiology and Mechanisms of Ectopic Hormone Production..- 10.3. Characteristics of the Ectopic Hormone Syndromes.- 10.4. Recent Developments in Specific Hormone Syndromes.- 10.5. Production of Nonhormonal Proteins and Other Syndromes by Malignant Disorders.- References.- 11 Current Concepts in Steroid Hormone Action.- 11.1. Introduction.- 11.2. Autoradiography.- 11.3. Receptor-Mediated Steroid Translocation to Nuclei.- 11.4. Quantitation of Nuclear Receptors by Nuclear Exchange..- 11.5. Cell-Free Binding Studies.- 11.6. Nature of the Nuclear Acceptor Site.- 11.7. Hormone Dependency of Nuclear Binding Receptors.- 11.8. Receptor Activation for Nuclear Binding.- 11.9. Correlation of Nuclear Binding with Biological Response.- 11.10. Cell Genetic Variants in Hormone Response.- 11.11. Quantitation of Transcriptional Events in Vitro.- 11.12. Gene Expression in the Chick Oviduct Model System.- 11.13. In Vivo Steroid-Induced Alterations in Chromatin Transcription Assayed in Vitro.- 11.14. Purification and Characterization of Chick Oviduct Progesterone Receptor.- 11.15. In Vitro Studies of Receptor-Mediated Alterations in Chromatin Transcription.- 11.16. Induction of Specific Gene Sequences by Progesterone Receptors in Vitro.- 11.17. Relationship of the Progesterone Receptor Subunit Structure to Its Effects on Differential Gene Expression.- 11.18. A Model for Steroid Hormone Action.- 11.19. Medical Relevance.- References.
1 Neuroendocrinology.- 1.1. Introduction.- 1.2. Neural Regulation of Endocrine Function.- 1.3. Hormone-Nervous System Interactions.- 1.4. Releasing Factors.- 1.5. Neuroendocrine Disease.- 1.6. The Pineal Gland.- References.- 2 Anterior Pituitary.- 2.1. Introduction.- 2.2. Corticotropin and Melanocyte-Stimulating Peptides.- 2.3. Thyrotropin.- 2.4. Gonadotropins.- 2.5. Prolactin.- 2.6. Somatotropin.- References.- 3 The Thyroid.- 3.1. Introduction.- 3.2. Neuroendocrine Regulation of Thyroid Function.- 3.3. Thyroid Hormones.- 3.4. Clinical Aspects of Thyroidology.- 3.5. Miscellaneous Aspects of Thyroidology.- References.- 4 The Ovary.- 4.1. Introduction.- 4.2. Estrogen Secretion Rates.- 4.3. Regulation of Follicular Growth.- 4.4. The Postmenopausal Ovary.- 4.5. Idiopathic Hirsutism.- 4.6. Side Effects of Estrogen.- References.- 5 The Testis.- 5.1. Introduction.- 5.2. Intrauterine and Neonatal Function.- 5.3. Puberty.- 5.4. Adult Physiology.- 5.5. Adult Pathophysiology.- 5.6. Influence of Other Disease on Testicular Function.- 5.7. Conclusions.- References.- 6 The Adrenal Cortex.- 6.1. Introduction.- 6.2. Corticosteroid Biosynthesis.- 6.3. Mechanism of Action of ACTH.- 6.4. Diseases of the Adrenal Cortex.- References.- 7 Aldosterone and the Renin-Angiotensin System.- 7.1. Introduction.- 7.2. Increased Aldosterone Production.- 7.3. Normal Aldosterone Production-Low-Renin Hypertension.- 7.4. Reduced Aldosterone Production.- References.- 8 Catecholamines and the Sympathoadrenal System.- 8.1. Introduction.- 8.2. Familial Pheochromocytoma and Multiple Endocrine Adenomatosis (MEA).- 8.3. Clinical Assessment of the Functional State of the Adrenal Medulla and the Sympathetic Nervous System.- 8.4. Hyperthyroidism and the Sympathoadrenal System.- References.- 9 Calcitonin.- 9.1.Introduction.- 9.2. Calcitonin.- References.- 10 Ectopic Hormone Syndromes.- 10.1. Introduction.- 10.2. Etiology and Mechanisms of Ectopic Hormone Production..- 10.3. Characteristics of the Ectopic Hormone Syndromes.- 10.4. Recent Developments in Specific Hormone Syndromes.- 10.5. Production of Nonhormonal Proteins and Other Syndromes by Malignant Disorders.- References.- 11 Current Concepts in Steroid Hormone Action.- 11.1. Introduction.- 11.2. Autoradiography.- 11.3. Receptor-Mediated Steroid Translocation to Nuclei.- 11.4. Quantitation of Nuclear Receptors by Nuclear Exchange..- 11.5. Cell-Free Binding Studies.- 11.6. Nature of the Nuclear Acceptor Site.- 11.7. Hormone Dependency of Nuclear Binding Receptors.- 11.8. Receptor Activation for Nuclear Binding.- 11.9. Correlation of Nuclear Binding with Biological Response.- 11.10. Cell Genetic Variants in Hormone Response.- 11.11. Quantitation of Transcriptional Events in Vitro.- 11.12. Gene Expression in the Chick Oviduct Model System.- 11.13. In Vivo Steroid-Induced Alterations in Chromatin Transcription Assayed in Vitro.- 11.14. Purification and Characterization of Chick Oviduct Progesterone Receptor.- 11.15. In Vitro Studies of Receptor-Mediated Alterations in Chromatin Transcription.- 11.16. Induction of Specific Gene Sequences by Progesterone Receptors in Vitro.- 11.17. Relationship of the Progesterone Receptor Subunit Structure to Its Effects on Differential Gene Expression.- 11.18. A Model for Steroid Hormone Action.- 11.19. Medical Relevance.- References.
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