The problem of creation a universal system of knowledge is connecting with the development of human civilization and the formation of all human culture. Therefore, this problem must be considered from this point of view.Conventionally, theories of everything can be divided into three classes: esoteric mythological, including numerology and Pythagorean system and main philosophies of whole; rational, first of all physical theories of everything, including the unified field theory and metascientific systems, including the polymetric analysis.All prehistoric cultural, mythological and philosophical systems can be divided into two types. The first refers to the ritual systems of the open type: the civilizations of the Mesopotamia of the Tigris and Euphrates, starting with Sumerian and ending with ancient Babylon.