Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders
Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Herausgeber: Rapozzi, Valentina; Bonavida, Benjamin; Xodo, Luigi
Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders
Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Herausgeber: Rapozzi, Valentina; Bonavida, Benjamin; Xodo, Luigi
Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both preclinical and clinical investigations. This book consists of the following: The program and abstracts presented at the Third International Conference in Udine, Italy, September 3-5, 2023; Parts I-V review on (I) the general properties…mehr
Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both preclinical and clinical investigations. This book consists of the following: The program and abstracts presented at the Third International Conference in Udine, Italy, September 3-5, 2023; Parts I-V review on (I) the general properties of nitric oxide in diseases; (II) the role of nitric oxide in cancer; (III) nitric oxide and immunity; (IV) nitric oxide and aging; and (V) nitric oxide and therapeutics. In addition, part VI is an educational review on artificial intelligence and its application in diseases. These updated reviews present many examples of research investigations related to the application of novel therapeutic compounds on nitric oxide and new derivatives, as well as their significant therapeutic activities against various resistant cancers that are unresponsive to current treatments and in different inflammatory disorders. This book is a valuable resource for cancer researchers, oncologists, graduate students, and investigators from medical and biomedical fields who want to learn more about NO and its therapeutic applications in cancer and inflammatory diseases. This book is also highly useful for both clinicians and oncologists as well as pharmaceutical companies involved in the development of new anticancer/antiinflammatory agents.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Contributors About the editors Preface UDINE 2023 Objective of this volume Highlights I General introduction 1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery Signori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli Emanuele Abbreviations Introduction Pathophysiology of CSA-AKI and NO dysregulation Renal vasoconstriction Direct free-hemoglobin and catalytic iron injury Ischemiaereperfusion injury Conclusions Conflict of interest statement Acknowledgments References II Nitric oxide and cancer 2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer Arduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara Tommasi Abbreviations Introduction Vasculogenic mimicry: Pathogenesis and clinical significance Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry General considerations Conflict of interest statement References III Nitric oxide reactions in the cells and models to check its biological properties 3. Decoding S-nitrosylation: Theoretical aspects and analytical approaches Gianmarco Matrullo, Chiara Pecorari, and Giuseppe Filomeni Abbreviations Introduction NO signaling Nitric oxide in physiology and pathology S-nitrosylation detection: Approaches and challenges Conclusion Conflict of interest Acknowledgments References 4. Preclinical models to assess the pharmacological properties of NO derivatives Lucia Morbidelli and Valerio Ciccone Abbreviations From preclinical to clinical trials of drugs Cell-based in vitro pharmacological screening and safety assessment Ex vivo experiments In vivo experiments to assess efficacy and safety of NO derivatives Conclusions Acknowledgements References IV Nitric oxide and neurodegeneration 5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration Jennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. Steinert Abbreviations Introduction Neurovascular oxidative and nitrergic stress Redox stress in the vascular, neuronal, and astrocytic compartments Therapeutic targets of NO signaling Conclusions Acknowledgments References V Nitric oxide and therapeutics 6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cells Mariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina Rapozzi Abbreviations Introduction Acknowledgments References Further reading 7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications Inesa Navasardyan and Benjamin Bonavida Abbreviations Introduction Treatment of GBM NO production and its biological process Role of the INOS/NO pathway in GBM NO-targeted therapies in GBM Discussion Perspectives and future directions Acknowledgments References 8. Nitric oxide donating systems and their potential in shaping tumor immunoregulation Greta Varchi Introduction The tumor microenvironment The enigmatic dual nature of nitric oxide in cancer Nitric oxide donors Nitric oxide donors and the immune system Conclusions and future directions References 9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer Eros Di Giorgio, Valentina Rapozzi, and Luigi E. Xodo Abbreviations Introduction NOS2 structure and function NOS2 and cancer Transcription factors activating NOS2 expression NRF2 controls the expression of NOS2 RF2 binds to a distal enhancer of NOS2 PDAC-spheroids formation depends on NOS2: Therapeutic implications Concluding remarks Conflict of interest References Further Reading 10. Nitric oxide in tumor biology: From stemness to metabolic reprogramming Antonio Rodríguez-Ariza Abbreviations Introduction Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer Role of NO in the biology of intestinal cancer cells Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer Conclusions Acknowledgments References 11. Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases Chaitali Ghosh, Mamta Sumi, and Arnab Ghosh Abbreviations Introduction Impact of NO on hemeprotein maturation NO in cancer Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression NO in asthma and pulmonary diseases Conclusion and future directions Acknowledgments References VI Educational session 12. Using artificial intelligence to discover new cancer therapies Apostolos Zaravinos Index 000
Contributors About the editors Preface UDINE 2023 Objective of this volume Highlights I General introduction 1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery Signori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli Emanuele Abbreviations Introduction Pathophysiology of CSA-AKI and NO dysregulation Renal vasoconstriction Direct free-hemoglobin and catalytic iron injury Ischemiaereperfusion injury Conclusions Conflict of interest statement Acknowledgments References II Nitric oxide and cancer 2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer Arduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara Tommasi Abbreviations Introduction Vasculogenic mimicry: Pathogenesis and clinical significance Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry General considerations Conflict of interest statement References III Nitric oxide reactions in the cells and models to check its biological properties 3. Decoding S-nitrosylation: Theoretical aspects and analytical approaches Gianmarco Matrullo, Chiara Pecorari, and Giuseppe Filomeni Abbreviations Introduction NO signaling Nitric oxide in physiology and pathology S-nitrosylation detection: Approaches and challenges Conclusion Conflict of interest Acknowledgments References 4. Preclinical models to assess the pharmacological properties of NO derivatives Lucia Morbidelli and Valerio Ciccone Abbreviations From preclinical to clinical trials of drugs Cell-based in vitro pharmacological screening and safety assessment Ex vivo experiments In vivo experiments to assess efficacy and safety of NO derivatives Conclusions Acknowledgements References IV Nitric oxide and neurodegeneration 5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration Jennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. Steinert Abbreviations Introduction Neurovascular oxidative and nitrergic stress Redox stress in the vascular, neuronal, and astrocytic compartments Therapeutic targets of NO signaling Conclusions Acknowledgments References V Nitric oxide and therapeutics 6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cells Mariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina Rapozzi Abbreviations Introduction Acknowledgments References Further reading 7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications Inesa Navasardyan and Benjamin Bonavida Abbreviations Introduction Treatment of GBM NO production and its biological process Role of the INOS/NO pathway in GBM NO-targeted therapies in GBM Discussion Perspectives and future directions Acknowledgments References 8. Nitric oxide donating systems and their potential in shaping tumor immunoregulation Greta Varchi Introduction The tumor microenvironment The enigmatic dual nature of nitric oxide in cancer Nitric oxide donors Nitric oxide donors and the immune system Conclusions and future directions References 9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer Eros Di Giorgio, Valentina Rapozzi, and Luigi E. Xodo Abbreviations Introduction NOS2 structure and function NOS2 and cancer Transcription factors activating NOS2 expression NRF2 controls the expression of NOS2 RF2 binds to a distal enhancer of NOS2 PDAC-spheroids formation depends on NOS2: Therapeutic implications Concluding remarks Conflict of interest References Further Reading 10. Nitric oxide in tumor biology: From stemness to metabolic reprogramming Antonio Rodríguez-Ariza Abbreviations Introduction Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer Role of NO in the biology of intestinal cancer cells Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer Conclusions Acknowledgments References 11. Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases Chaitali Ghosh, Mamta Sumi, and Arnab Ghosh Abbreviations Introduction Impact of NO on hemeprotein maturation NO in cancer Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression NO in asthma and pulmonary diseases Conclusion and future directions Acknowledgments References VI Educational session 12. Using artificial intelligence to discover new cancer therapies Apostolos Zaravinos Index 000
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