The thermodynamic and acoustical properties are very essential for understanding the physiochemical behavior of binary liquid systems. Excess properties of binary liquid systems like excess molar volume and excess compressibilities are used for testing the various theories of binary liquid systems. This book investigates the thermodynamic and physiochemical properties of binary liquid systems. In this work, we have calculated various thermodynamic and acoustical parameters theoretically, for the prediction of variation in properties and the intermolecular interactions of binary liquid systems.