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High Quality Content by WIKIPEDIA articles! Third Pandemic is the designation of a major plague pandemic that began in the Yunnan province in China in 1855. This episode of bubonic plague spread to all inhabited continents, and ultimately killed more than 12 million people in India and China alone. According to the World Health Organization, the pandemic was considered active until 1959, when worldwide casualties dropped to 200 per year. Bubonic plague is an infectious disease that is widely thought to have caused several epidemics or pandemics throughout history, including two previous pandemics commonly designated as the Plague of Justinian and the Black Death. New research suggests Black Death is lying dormant.