Thymic Development and Selection of T Lymphocytes

Herausgegeben:Boehm, Thomas; Takahama, Yousuke

• Broschiertes Buch

Produktbeschreibung

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Produktdetails

• Current Topics in Microbiology and Immunology 373
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-662-51196-1
• Softcover reprint of the original 1st ed. 2014
• Seitenzahl: 132
• Englisch
• Abmessung: 7mm x 155mm x 235mm
• Gewicht: 225g
• ISBN-13: 9783662511961
• ISBN-10: 3662511967
• Artikelnr.: 45509621

Inhaltsangabe

Development and Function of Cortical Thymic Epithelial Cells.- Mechanisms of Thymus Medulla Development And Function.- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction.- Trafficking to the Thymus.- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.