The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins--proteins originally isolated from the thymus and possess a unique array of biological properties. Thymosins in Health and Disease I brings together short reviews organized to explore the basic characteristics of these peptides and their hormone-like properties, recent preliminary evidence for their medicinal utility, and a focus on the alpha and beta thymosin families. In particular, Thymosin β4 (Tβ4) holds considerable promise for the treatment of many conditions and diseases. Of note,…mehr
The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins--proteins originally isolated from the thymus and possess a unique array of biological properties. Thymosins in Health and Disease I brings together short reviews organized to explore the basic characteristics of these peptides and their hormone-like properties, recent preliminary evidence for their medicinal utility, and a focus on the alpha and beta thymosin families. In particular, Thymosin β4 (Tβ4) holds considerable promise for the treatment of many conditions and diseases. Of note, contributions to this volume include information on the application of thymosins to stem cell differentiation, neurological and cardiovascular regeneration, as well as accounts of thymosins in relation to basic regulatory and cancer cell functions. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http: //ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world-renowned authority on the thymus gland and the workings of the immune system, and co-discoverer of the thymosins. Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience. He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co-founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals. Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.
Inhaltsangabe
Introduction for Thymosins in Health and Disease vii Allan L. Goldstein and Enrico Garaci Thymosins: chemistry, genetics, receptors, signaling, and multifunctionality Jack of all trades: thymosin 1 and its pleiotropy 1 Luigina Romani, Silvia Moretti, Francesca Fallarino, Silvia Bozza, Loredana Ruggeri, Andrea Casagrande, Franco Aversa, Francesco Bistoni, Andrea Velardi, and Enrico Garaci Single-domain ß-thymosins: the family history 7 John Edwards Controlled delivery of thymosin ß4 for tissue engineering and cardiac regenerative medicine 16 Loraine L. Y. Chiu, Lewis A. Reis, and Milica Radisic Thymosin 1 and cancer: action on immune effector and tumor target cells 26 Enrico Garaci, Francesca Pica, Annalucia Serafino, Emanuela Balestrieri, Claudia Matteucci, Gabriella Moroni, Roberta Sorrentino, Manuela Zonfrillo, Pasquale Pierimarchi, and Paola Sinibaldi-Vallebona Prothymosin plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms 34 Hiroshi Ueda, Hayato Matsunaga, and Sebok Kumar Halder Thymosin ß4 is rapidly internalized by cells and does not induce intracellular Ca² elevation 44 Czeslaw S. Cierniewski, Katarzyna Sobierajska, Anna Selmi, Jakub Kryczka, and Radoslaw Bednarek Thymosins: molecular markers, wound healing, fibrosis, inflammation, and hypoxia Thymosin ß4 expression reveals intriguing similarities between fetal and cancer cells 53 Carvino Faa, Sonia Nemolato, Tiziana Cabras, Daniela Fanni, Clara Gerosa, Mattia Fanari, Annalisa Locci, Vassilios Fanos, Irene Messana, and Massimo Castagnola Protective effects of thymosin ß4 on carbon tetrachloride-induced acute hepatotoxicity in rats 61 Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Marcos Rojkind, and M. Raj Lakshman Protective effects of thymosin ß4 in a mouse model of lung fibrosis 69 Enrico Conte, Tiziana Genovese, Elisa Gili, Emanuela Esposito, Maria Iemmolo, Mary Fruciano, Evelina Fagone, Maria Provvidenza Pistorio, Nunzio Crimi, Salvatore Cuzzocrea, and Carlo Vancheri Thymosin ß4 affecting the cytoskeleton organization of the myofibroblasts 74 H. Paul Ehrlich and Sprague W. Hazard Thymosin ß4 stabilizes hypoxia-inducible factor-1 protein in an oxygen-independent manner 79 Mee Sun Ock, Kyoung Seob Song, Hynda Kleinman, and Hee-Jae Cha Thymosin ß4: cardiovascular protection, neuroplasticity and regeneration, and stem cell differentiation Thymosin ß4 and cardiac protection: implication in inflammation and fibrosis 84 Sudhiranjan Gupta, Sandeep Kumar, Nikolai Sopko, Yilu Qin, Chuanyu Wei, and Il-Kwon Kim Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart 92 Nicola Smart, Sveva Bollini, Karina D. Dubé, Joaquim M. Vieira, Bin Zhou, Johannes Riegler, Anthony N. Price, Mark F. Lythgoe, Sean Davidson, Derek Yellon, William T. Pu, and Paul R. Riley Molecular and cellular mechanisms of thymosin ß4-mediated cardioprotection 102 Rabea Hinkel, Teresa Trenkwalder, and Christian Kupatt Treatment of neurological injury with thymosin ß4 110 Daniel C. Morris, Zheng G. Zhang, Jing Zhang, Ye Xiong, Li Zhang, and Michael Chopp Therapeutic potential of thymosin ß4 in myocardial infarct and hear failure 117 Christoffer Stark, Pekka Taimen, Miikka Tarkia, Jussi Pärkkä, Antti Saraste, Tero-Pekka Alastalo, Timo Savunen, and Juha Koskenvuo Thymosin ß4 mobilizes mesothelial cells for blood vessel repair 125 Elaine L. Shelton and David M. Bader Appendix: Historical article reprinted from Annals of the New York Academy of Sciences 332: 33-48 (1979) Current status of thymosin research: Evidence for the existence of a family of thymic factors that control T-cell maturation 131 Teresa L. K. Low, Gary B. Thurman, Carolina Chincarini, John E. McClure, Gailen D. Marshalll, Shu-Kuang Hu, and Allan L. Goldstein
Introduction for Thymosins in Health and Disease vii Allan L. Goldstein and Enrico Garaci Thymosins: chemistry, genetics, receptors, signaling, and multifunctionality Jack of all trades: thymosin 1 and its pleiotropy 1 Luigina Romani, Silvia Moretti, Francesca Fallarino, Silvia Bozza, Loredana Ruggeri, Andrea Casagrande, Franco Aversa, Francesco Bistoni, Andrea Velardi, and Enrico Garaci Single-domain ß-thymosins: the family history 7 John Edwards Controlled delivery of thymosin ß4 for tissue engineering and cardiac regenerative medicine 16 Loraine L. Y. Chiu, Lewis A. Reis, and Milica Radisic Thymosin 1 and cancer: action on immune effector and tumor target cells 26 Enrico Garaci, Francesca Pica, Annalucia Serafino, Emanuela Balestrieri, Claudia Matteucci, Gabriella Moroni, Roberta Sorrentino, Manuela Zonfrillo, Pasquale Pierimarchi, and Paola Sinibaldi-Vallebona Prothymosin plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms 34 Hiroshi Ueda, Hayato Matsunaga, and Sebok Kumar Halder Thymosin ß4 is rapidly internalized by cells and does not induce intracellular Ca² elevation 44 Czeslaw S. Cierniewski, Katarzyna Sobierajska, Anna Selmi, Jakub Kryczka, and Radoslaw Bednarek Thymosins: molecular markers, wound healing, fibrosis, inflammation, and hypoxia Thymosin ß4 expression reveals intriguing similarities between fetal and cancer cells 53 Carvino Faa, Sonia Nemolato, Tiziana Cabras, Daniela Fanni, Clara Gerosa, Mattia Fanari, Annalisa Locci, Vassilios Fanos, Irene Messana, and Massimo Castagnola Protective effects of thymosin ß4 on carbon tetrachloride-induced acute hepatotoxicity in rats 61 Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Marcos Rojkind, and M. Raj Lakshman Protective effects of thymosin ß4 in a mouse model of lung fibrosis 69 Enrico Conte, Tiziana Genovese, Elisa Gili, Emanuela Esposito, Maria Iemmolo, Mary Fruciano, Evelina Fagone, Maria Provvidenza Pistorio, Nunzio Crimi, Salvatore Cuzzocrea, and Carlo Vancheri Thymosin ß4 affecting the cytoskeleton organization of the myofibroblasts 74 H. Paul Ehrlich and Sprague W. Hazard Thymosin ß4 stabilizes hypoxia-inducible factor-1 protein in an oxygen-independent manner 79 Mee Sun Ock, Kyoung Seob Song, Hynda Kleinman, and Hee-Jae Cha Thymosin ß4: cardiovascular protection, neuroplasticity and regeneration, and stem cell differentiation Thymosin ß4 and cardiac protection: implication in inflammation and fibrosis 84 Sudhiranjan Gupta, Sandeep Kumar, Nikolai Sopko, Yilu Qin, Chuanyu Wei, and Il-Kwon Kim Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart 92 Nicola Smart, Sveva Bollini, Karina D. Dubé, Joaquim M. Vieira, Bin Zhou, Johannes Riegler, Anthony N. Price, Mark F. Lythgoe, Sean Davidson, Derek Yellon, William T. Pu, and Paul R. Riley Molecular and cellular mechanisms of thymosin ß4-mediated cardioprotection 102 Rabea Hinkel, Teresa Trenkwalder, and Christian Kupatt Treatment of neurological injury with thymosin ß4 110 Daniel C. Morris, Zheng G. Zhang, Jing Zhang, Ye Xiong, Li Zhang, and Michael Chopp Therapeutic potential of thymosin ß4 in myocardial infarct and hear failure 117 Christoffer Stark, Pekka Taimen, Miikka Tarkia, Jussi Pärkkä, Antti Saraste, Tero-Pekka Alastalo, Timo Savunen, and Juha Koskenvuo Thymosin ß4 mobilizes mesothelial cells for blood vessel repair 125 Elaine L. Shelton and David M. Bader Appendix: Historical article reprinted from Annals of the New York Academy of Sciences 332: 33-48 (1979) Current status of thymosin research: Evidence for the existence of a family of thymic factors that control T-cell maturation 131 Teresa L. K. Low, Gary B. Thurman, Carolina Chincarini, John E. McClure, Gailen D. Marshalll, Shu-Kuang Hu, and Allan L. Goldstein
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