Regeneration of the periodontal tissues is a complex phenomenon requiring interplay between various processes in a timely manner.Research strives to attain regeneration in a more predictable, quicker, less invasive ways than allowed by previous techniques. Tissue engineering is a highly promising field of reconstructive biology that draws on recent advances in medicine, surgery, molecular and cellular biology, polymer chemistry and physiology. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors, to allow growth and specialization of cells and matrix. This book is a brief review on the basics of tissue engineering related to Periodontology and also updates the reader with the controlled clinical trials that prove the ability of tissue engineering in achieving new heights in periodontal regeneration.