Tissue engineering is a rapidly emerging field, with great potential, to profoundly improve patient care. It aims to develop procedures and biomaterials to facilitate the development of new tissues to replace damaged tissues, based on the principles of cell biology, developmental biology, and biomaterials science. The major goal of periodontal tissue engineering is to harness the body's own capacity to regenerate functionally active periodontal tissue. This regeneration in this process totally depend on physiological responds to metabolic cues rather than to replace tissue with grafts and metallic devices, that are currently available in the market.