The purpose of the presented monograph is to provide scientific information on the botanical features, traditional uses, active or major chemical constituents and pharmacology of Tithonia diversifolia. Studies on purified principles, mechanism of action and structure activity relationship are relatively few and warrant further attention as traditional literature assures Tithonia diversifolia for the discovery of novel therapeutic agent(s). The safety, efficacy, quality control/quality assurance, clinical applications, contra indications, warnings, precautions, potential adverse reactions, and posology are not the part as very little data available regarding discussed plant. However, it helps in facilitating information exchange among practitioners of orthodox and of traditional medicine, pharmacists and other health professionals, manufacturers of herbal products and research scientists and assist in developing their own monographs or formularies.