Vikas Jhawat, Monika Gulia

Topical Pluronic Lecithin Organogel for Pain Management

Formulation and evaluation of novel controlled release topical pluronic lecithin organogel of mefenamic acid

• Broschiertes Buch

Produktbeschreibung

Pluronic lecithin based organogels were formulated as topical carrier for controlled delivery of mefenamic acid, an analgesic and anti-inflammatory drug practically insoluble in water. The organogels were prepared by method employing lecithin and pluronic as oil phase and aqueous phase respectively. Isopropyl myristate (IPM) was used as organic solvent for lecithin, whereas gelation was achieved by slowly addition of aqueous phase (Pluronic). Ten formulations were prepared using varying concentration of lecithin and pluronic. Increase in the amount of lecithin resulted in organogels with higher viscosity and lower spreadability and same pattern was followed when pluronic with varying concentrations was used. Organogels with higher viscosity were found to be more stable and controlling the release rate. All formulations were found to have pH value within the range of 5.56-5.80 i.e. within skin pH range. So none of the formulations were found irritant to the skin. In vitro release of mefenamic acid from organogels showed that organogels containing 2% lecithin (F2) gave highest release in 8 hours.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 164
• Englisch
• Abmessung: 220mm x 150mm
• ISBN-13: 9786206789512
• Artikelnr.: 69464190

Autorenporträt

Dr. Vikas Jhawat specializes in the field of polymer-based dosage formulation development, utilizing innovative techniques. He possesses practical expertise in utilizing advanced instrumentation such as HPLC, GC, UV spectroscopy, FTIR, and various other analytical tools. He was honored with the Young Scientist award in 3rd North Zone Conference.