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This book is an attempt to study how the synergetic combination of Total Quality Management practices in pharmaceutical companies create the impact in organizational development and change in the pharmaceutical industry and radical changes to the society. The prominence has been on increasing focus on Total Quality Management Practices and its challenges of implementation. The Total Quality Management-based change of structural equation modelling (SEM) has been developed in this book. In addition to that with a particular focus on TQM practices and their social relevance is also detailed in this book. The level of Total Quality Management practices in pharmaceutical companies is measured with organizational practices such as human resource management practices, financial management practices, marketing management practices, operations management practices, environmental management practices, quality circles, and its other pre-identified variables. The managerial, functional, environmental, and social dimensions are also often used to measure the final outcome and social relevance of Total Quality Management Practices in Pharmaceutical companies in India. Moreover, Total Quality Management Practices has been shown to contribute to organizational performance and social pertinence. It seems that most of the pharmaceutical companies are practicing TQM but very few companies are inactive in this philosophy. So the Total Quality Management Practices are inevitable to facilitate organizational development and change. The ability to identify and measure the challenges of TQM is essential for the implementation of this practice. Apart from the above the book also reveals the unforeseen changes during Covid 19 pandemic in Total Quality Management Practices in Pharmaceutical companies. This book discloses and implicates the different aspects and benefits of environmental management practices and evaluates the final outcome of this practice. The effectiveness of the quality circle suggests that there will be an organizational development and change in the pharmaceutical companies for continuous improvement which is implied in Total Quality Management Practices. The result shows that the TQM practices in pharmaceutical companies are very much socially relevant and create radical changes in the society.