Total Synthesis of Callipeltin E and Towards Papuamide B - CALIMSIZ, SELCUK
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Callipeltins and Papuamides -novel families of cyclic depsipeptides- were shown to possess potent anti-HIV activity as well as cytotoxicity against several multidrug resistant cancer cell lines. The novel structural features and diverse biological effects of these peptides metabolites have generated considerable interest among synthetic chemistry groups. In this book, discovery of the lanthanide catalyzed transamidation of Fmoc protected lactams, solid-phase synthesis and configurational reassignment of Callipeltin E, synthesis of N-Fmoc- (2S,3S,4R)-3,4-dimethylglutamine and an efficient…mehr

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Produktbeschreibung
Callipeltins and Papuamides -novel families of cyclic
depsipeptides- were shown to possess potent anti-HIV
activity as well as cytotoxicity against several
multidrug resistant cancer cell lines. The novel
structural features and diverse biological effects
of these peptides metabolites have generated
considerable interest among synthetic chemistry
groups. In this book, discovery of the lanthanide
catalyzed transamidation of Fmoc protected lactams,
solid-phase synthesis and configurational
reassignment of Callipeltin E, synthesis of N-Fmoc-
(2S,3S,4R)-3,4-dimethylglutamine and an efficient
method for the on-resin synthesis and
macrocylization of a simplified Papuamide B model
system are summarized.
Autorenporträt
Born on September, 12th 1975 in Ankara, Turkey; 1994-1998 B.Sc.
in Chemistry (with honors) at Ankara University, Faculty of
Science, Ankara, Turkey; 2001-2003 M.Sc. in Chemical Education
and 2003-2007 Ph.D. in Organic Chemistry at Purdue University,
Department of Chemistry, West Lafayette, IN, USA.