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Many scientists now widely agree that the current paradigm of statistical significance should be abandoned or largely modified. In response to these calls for change, a Special Issue of Econometrics (MDPI) has been proposed. This book is a collection of the articles that have been published in this Special Issue. These seven articles add new insights to the problem and propose new methods that lay a solid foundation for the new paradigm for statistical significance. Many scientists now widely agree that the current paradigm of statistical significance should be abandoned or largely modified. In response to these calls for change, a Special Issue of Econometrics (MDPI) has been proposed. This book is a collection of the articles that have been published in this Special Issue. These seven articles add new insights to the problem and propose new methods that lay a solid foundation for the new paradigm for statistical significance.