Toxicology of Glutathione Transferases

Herausgeber: Awasthi, Yogesh C

• Broschiertes Buch

Produktbeschreibung

The most important enzymes protecting human and other organisms from potentially toxic chemicals, Glutathione S-transferases (GSTs) are central to basic mechanisms such as stress response and physiological functions including protection against lipid peroxidation. This book describes the role of GST in toxicology, focusing on their pharmacologic and physiological roles and their relevance to biological toxicology. It covers structure and function, gene regulation, and these enzymes' involvement in signal transduction. Reflecting current trends in this expanding research area, Toxicology of Glutathione Transferases is the only source that details the methods of GST research.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 400
• Erscheinungstermin: 23. Oktober 2019
• Englisch
• Abmessung: 234mm x 155mm x 23mm
• Gewicht: 839g
• ISBN-13: 9780367390532
• ISBN-10: 0367390531
• Artikelnr.: 58051558

Autorenporträt

Yogesh C. Awasthi

Inhaltsangabe

Preface.Ligandin and Glutathione S-Transferases; Historical Milestones.
Families of Glutathione Transferases.Mammalian Glutathione S-Transferase
Genes: Structure and Regulation. Combinatorial Protein Chemistry In Three
Dimensions: A Paradigm For The Evolution Of Glutathione Transferases With
Novel Activities. Substrates and Reaction Mechanisms of GSTs. Specificity
of Glutathione S-Transferases in the Glutathione Conjugation of
Carcinogenic Diol Epoxides. GST Polymorphism: Where To Now? Clinical
Applications and Functional Analysis. Glutathione and Glutathione
S-Transferases as Targets for Anticancer Drug Development.Physiological
Substrates of Glutathione S-Transferases. Glutathione S-transferases as
modulators of signal transduction. Glutathione-conjugate transport and
Stress-Response Signaling: Role of RLIP76. Glutathione-S-Transferases and
Oxidative Injury of Cardiovascular Tissues. Mitochondrial Glutathione
S-Transferase Pool in Health and Disease. Activation of Microsomal
Glutathione Transferase 1 in Toxicology. Glutathione S-transferase Isozyme
Composition of Human Tissues. Enzymology of glutathione S-transferases:
Laboratory Methods.