This second edition looks at the physiologic, biochemical, and morphologic characteristics of hepatotoxicity and includes an analysis of techniques in molecular biology and immunochemistry, among others contributing to the growth in understanding of the toxic events involved. It focuses on clinical characterization of chemical hepatotoxicity, microscopic characteristics of the mechanisms by which chemicals can produce liver injury and experimental models useful for the study of liver dysfunction.
This second edition looks at the physiologic, biochemical, and morphologic characteristics of hepatotoxicity and includes an analysis of techniques in molecular biology and immunochemistry, among others contributing to the growth in understanding of the toxic events involved. It focuses on clinical characterization of chemical hepatotoxicity, microscopic characteristics of the mechanisms by which chemicals can produce liver injury and experimental models useful for the study of liver dysfunction.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1. Drug-induced Hepatic Disease Hyman Zimmerman 2. Morphological Characteristics of Chemical-induced Hepatotoxicity in Laboratory Rodents Paul Newberne and James Newberne 3. Chemical Induced Hepatocarcinogenesis James Klaunig and Kyle Kolaja 4. An Overview of Peroxisome Proliferation Jeffrey Lawrence and Patrick Eacho 5. Acetaminophen-induced Hepatotoxicity Steven Cohen Debie Hoivik and Edward Khairallah 6. Evaluation of Chemical-induced Oxidative Stress as a Mechanism of Hepatocyte Death Donald Reed 7. Lipid Peroxidation as a Mediator of Chemical-induced Hepatocyte Death Mario Comporti 8. Immunologic Meditation of Chemical-induced Hepatotoxicity Sylvia Furst Jay Gandolfi 9. The Role of Nonpharenchymal Cells and Inflammatory Macrophages in Hepatotoxicity Debra Laskin and Carol Gardner 10. Cholestatic Properties of Steroid Glucuronides Mary Vore and Kim Brouwer 11. Mechanisms Involved in Bile Acid-induced Cholestasis Ibrahim Yousef Guylaine Bouchard Beatriz Tuchweber and Gabriel Plaa 12. Cholestasis Produced by Combinations of Manganese and Bilirubin Gabriel Plaa Alexandra Duguay Lena King and William Hewitt 13. Evaluation of Chemical-induced Bile Duct Proliferation Claude Barriault Alexis Desmouliere Andrea Monte Alto Costa Ibrahim Yousef and Beatriz Tuchweber. Guylaine Bouchard University of Montreal Canada Kim Brouwer University of North Carolina USA Steven Cohen University of Connecticut USA Mario Comporti University of Siena Italy Andrea Monte Alto Costa Universidade do Estado do Rio de Janeiro Brazil Alexis Desmouliere Institut de Biologie et Chimie des Proteines France Alexandra Duguay University of Montreal Canada Patrick Eacho Lilly Research Laboritories USA Sylvia Furst Boehringer Ingelheim Pharmaceuticals USA Jay Gandolfi University of Arizona USA Carol Gardner Rutgers University USA William Hewitt SmithKline Beecham Pharmaceuticals USA Debie Hoivik Texas A&M University USA Edward Khairallah Deceased Lena King Parke Davis Research Institute Canada James Klaunig Indiana University School of Medicine USA Kyle Kolaja Indiana University School of Medicine USA Debra Laskin Rutgers University USA Jeffrey Lawrence Merck Research Laboratories USA James Newberne University of Cincinatti USA Paul Newberne Boston University School of Medicine USA Gabriel Plaa University of Montreal Canada Donald Reed Oregan State University USA Beatriz Tuchweber University of Montreal Canada Mary Vore University of Kentucky USA Ibrahim Yousef University of Montreal Canada Hyman Zimmerman George Washington University USA.
1. Drug-induced Hepatic Disease Hyman Zimmerman 2. Morphological Characteristics of Chemical-induced Hepatotoxicity in Laboratory Rodents Paul Newberne and James Newberne 3. Chemical Induced Hepatocarcinogenesis James Klaunig and Kyle Kolaja 4. An Overview of Peroxisome Proliferation Jeffrey Lawrence and Patrick Eacho 5. Acetaminophen-induced Hepatotoxicity Steven Cohen Debie Hoivik and Edward Khairallah 6. Evaluation of Chemical-induced Oxidative Stress as a Mechanism of Hepatocyte Death Donald Reed 7. Lipid Peroxidation as a Mediator of Chemical-induced Hepatocyte Death Mario Comporti 8. Immunologic Meditation of Chemical-induced Hepatotoxicity Sylvia Furst Jay Gandolfi 9. The Role of Nonpharenchymal Cells and Inflammatory Macrophages in Hepatotoxicity Debra Laskin and Carol Gardner 10. Cholestatic Properties of Steroid Glucuronides Mary Vore and Kim Brouwer 11. Mechanisms Involved in Bile Acid-induced Cholestasis Ibrahim Yousef Guylaine Bouchard Beatriz Tuchweber and Gabriel Plaa 12. Cholestasis Produced by Combinations of Manganese and Bilirubin Gabriel Plaa Alexandra Duguay Lena King and William Hewitt 13. Evaluation of Chemical-induced Bile Duct Proliferation Claude Barriault Alexis Desmouliere Andrea Monte Alto Costa Ibrahim Yousef and Beatriz Tuchweber. Guylaine Bouchard University of Montreal Canada Kim Brouwer University of North Carolina USA Steven Cohen University of Connecticut USA Mario Comporti University of Siena Italy Andrea Monte Alto Costa Universidade do Estado do Rio de Janeiro Brazil Alexis Desmouliere Institut de Biologie et Chimie des Proteines France Alexandra Duguay University of Montreal Canada Patrick Eacho Lilly Research Laboritories USA Sylvia Furst Boehringer Ingelheim Pharmaceuticals USA Jay Gandolfi University of Arizona USA Carol Gardner Rutgers University USA William Hewitt SmithKline Beecham Pharmaceuticals USA Debie Hoivik Texas A&M University USA Edward Khairallah Deceased Lena King Parke Davis Research Institute Canada James Klaunig Indiana University School of Medicine USA Kyle Kolaja Indiana University School of Medicine USA Debra Laskin Rutgers University USA Jeffrey Lawrence Merck Research Laboratories USA James Newberne University of Cincinatti USA Paul Newberne Boston University School of Medicine USA Gabriel Plaa University of Montreal Canada Donald Reed Oregan State University USA Beatriz Tuchweber University of Montreal Canada Mary Vore University of Kentucky USA Ibrahim Yousef University of Montreal Canada Hyman Zimmerman George Washington University USA.
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