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Trace elements are minerals present in the human body in very low doses, they are essential for its functioning because they actively participate in practically all the metabolic reactions of the body.Despite a balanced diet, a deficiency in trace elements can be observed in certain circumstances such as pregnancy.We propose in this work to study the variations during pregnancy of three trace elements and the main proteins involved in their metabolism: iron, zinc, copper, ferritin, soluble transferrin receptors and ceruloplasmin d. on the one hand, and to note on the other hand a possible maternal-fetal impact.