Andere Kunden interessierten sich auch für
![Enhancer Mediated Mechanisms of Transcription]( "Enhancer Mediated Mechanisms of Transcription")
Enhancer Mediated Mechanisms of Transcription32,99 €![Polymorphisms in Estrogen Receptor Genes and Breast Cancer Risk]( "Polymorphisms in Estrogen Receptor Genes and Breast Cancer Risk")
Polymorphisms in Estrogen Receptor Genes and Breast Cancer Risk51,99 €![regulation of 5-HT1A receptor gene]( "regulation of 5-HT1A receptor gene")
regulation of 5-HT1A receptor gene44,99 €![A phenotypic study of G protein-coupled receptor 30 mutant mice]( "A phenotypic study of G protein-coupled receptor 30 mutant mice")
A phenotypic study of G protein-coupled receptor 30 mutant mice38,99 €![Insulin receptor gene and associated mutations]( "Insulin receptor gene and associated mutations")
Insulin receptor gene and associated mutations32,99 €![T-cell Receptor Gamma Gene Rearrangement in T-cell Neoplasm]( "T-cell Receptor Gamma Gene Rearrangement in T-cell Neoplasm")
T-cell Receptor Gamma Gene Rearrangement in T-cell Neoplasm46,99 €![Transcription Factors]( "Transcription Factors")
Transcription Factors261,99 €
Studies carried out during the past decade have
shown that transcription of inducible
eukaryotic genes involves sequential chromatin
modifications by promoter-specific transcription
factors and a class of proteins called transcription
coregulators. First, this work identifed
important chromatin modifications and modifying
complexes at the CYP17 transcription start site and
nearby steroidogenic factor-1 (SF-1) binding site.
Post translational modifications (PTMs) to SF-1 also
occur as this transcription factor interacts with
the promoter. In addition, ACTH/cAMP signaling in
adrenal cortex alters SF-1-containing chromatin-
modifying complexes during the early phase of
transcriptional induction of CYP17. Chromatin
IP (ChIP) and mammalian two hybrid experiments
identified complexes which are cAMP-inducible, but
sensitive to the SF-1 antagonist sphingosine. SF-1
PTMs at the ligand binding pocket opening were found
to be required for CYP17 transcription. Last,
certain corepressors are protein kinase A
(PKA) targets and are functionally sensitive to PKA-
dependent NADH accumulation. Thus, signaling,
metabolism, and transcription are integrated.
shown that transcription of inducible
eukaryotic genes involves sequential chromatin
modifications by promoter-specific transcription
factors and a class of proteins called transcription
coregulators. First, this work identifed
important chromatin modifications and modifying
complexes at the CYP17 transcription start site and
nearby steroidogenic factor-1 (SF-1) binding site.
Post translational modifications (PTMs) to SF-1 also
occur as this transcription factor interacts with
the promoter. In addition, ACTH/cAMP signaling in
adrenal cortex alters SF-1-containing chromatin-
modifying complexes during the early phase of
transcriptional induction of CYP17. Chromatin
IP (ChIP) and mammalian two hybrid experiments
identified complexes which are cAMP-inducible, but
sensitive to the SF-1 antagonist sphingosine. SF-1
PTMs at the ligand binding pocket opening were found
to be required for CYP17 transcription. Last,
certain corepressors are protein kinase A
(PKA) targets and are functionally sensitive to PKA-
dependent NADH accumulation. Thus, signaling,
metabolism, and transcription are integrated.