Broschiertes Buch

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Basic and Clinical Biology

Herausgegeben: Jakowlew, Sonia B.;Mitarbeit: Sporn, M.B.

Beschreibung

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology

Produktdetails

• Cancer Drug Discovery and Development
• Verlag: Humana / Humana Press / Springer, Berlin
• Seitenzahl: 735
• Erscheinungstermin: 19. November 2010
• Englisch
• Abmessung: 254mm x 178mm x 38mm
• Gewicht: 1403g
• ISBN-13: 9781617377358
• ISBN-10: 161737735X
• Artikelnr.: 32208974

Rezensionen

From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. ... will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease ... . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody's Review Service, May, 2008)