Translational Gastroenterology

Herausgeber: Eltorai, Adam E M; Horvath, Karoly; Mehta, Devendra; Liu, Tao

• Broschiertes Buch

Produktbeschreibung

Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. Readers will learn important concepts, including case-control study, prospective cohort study, randomized trials, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it.

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Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 308
• Erscheinungstermin: 1. April 2025
• Englisch
• ISBN-13: 9780128214268
• ISBN-10: 0128214260
• Artikelnr.: 71811339

Inhaltsangabe

PART I: CONCEPT 1. Introduction to clinical research 2. The question 3. Study population 4. Outcome measurements PART II: STUDY TYPES 5. Design principles 6. Case series 7. Case-control study 8. Cohort study 9. Cross-section study 10. Clinical trials 11. Meta-analysis 12. Cost-effectiveness study 13. Diagnostic test evaluation 14. Reliability study 15. Database studies 16. Surveys and questionnaires 17. Qualitative methods and mixed methods
Definition of the study type PART III: CLINICAL TRIALS 17. Randomized control 18. Nonrandomized control 19. Historical control 20. Cross-over 21. Withdrawal studies 22. Factorial design 23. Group allocation 24. Hybrid design 25. Large, pragmatic 26. Equivalence and noninferiority 27. Adaptive 28. Randomization 30. Multicenter considerations
Study design and practical considerations PART IV: PLANNING 31. Optimizing the question 32. Meaningful outcome measurements
33. Sample size
Power analysis 34. Budgeting
Funding, timeline, personnel, materials 35. Ethics and review boards
36. Regulatory considerations for new drugs and devices
37. Funding approaches
38. Research team
39. Subject recruitment
40. Data management
41. Quality control
42. Report forms 43. Subject adherence
44. Survival analysis
45. Monitoring committee in clinical trials PART V: STATISTICAL PRINCIPLES 46. Presenting datä 47. Common issues in analysis
48. Basic statistical principles
49. Distributions
Description, examples, implications in analysis. 50. Hypotheses and error types
51. Power
Detecting effects 52. Regression
Explanation 53. t-test
Explanation 54. Chi-square
Explanation 55. Analysis of variance
Explanation 56. Correlation
Explanation 57. Biases