Translational Neuroscience

A Guide to a Successful Program
Herausgegeben von Garcia-Rill, Edgar

• Gebundenes Buch

Produktbeschreibung

Translational research looks to take the latest innovations made in the laboratory setting to translate findings into effective and sustainable medical interventions and improved preventative measures. Funding support is increasingly tied to practical healthcare outcomes, with this trend likely only to increase in coming years, Translational Neuroscience: A Guide to a Successful Program, is a timely guide to developing research programs that bring translational advances to the forefront.

Translational Neuroscience provides practical information from scientists with first-hand experience in developing a cutting-edge translational facility. The book opens with chapters that provide guidance to organizing a center for translational science. Chapters look at topics ranging from mentoring and career planning for clinician scientists to improving the design of core facilities and addressing infrastructure needs. The second half of the book provides valuable case studies of translational neuroscience in action, with examples ranging from using to transcranial magnetic stimulation to studies on drug abuse and telemedicine applications. The final chapter looks to the future of basic science research, how academic health centers can be reorganized, and how future generations of translational neuroscientists can be trained.

Translational Neuroscience provides a blueprint to developing an innovative and successful translational research program. Deans, department chairs, academic health center administrators, and researchers will find this guide useful for drafting programs in translational research and avoiding costly pitfalls. While grounded in examples from basic neuroscience research, this book will be a useful tool to all scientists looking to develop centers of translational science across research disciplines.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 168
• Erscheinungstermin: 7. Februar 2012
• Englisch
• Abmessung: 244mm x 170mm x 15mm
• Gewicht: 666g
• ISBN-13: 9780470960714
• ISBN-10: 047096071X
• Artikelnr.: 34556791

Autorenporträt

Edgar Garcia-Rill is Professor of Anatomy and Psychiatry at the University of Arkansas for Medical Sciences. His research interests include sleep disorders, schizophrenia, depression, PTSD, and aches Neuroscience spinal cord injury. Dr. Garcia-Rill is also Director of the Center for Translational Neuroscience, a didivision of division of the Department of Neurobiology & Dev. Sci. and a research arm of the Jackson T. Stephens Spine & Neuroscience Institute, at which novel treatments for the treatment of spinal cord injury are are being developed under the Spinal Cord Injury Mobilization Program.

Inhaltsangabe

Contributors xi Preface xiii Acknowledgments xv 1 A Brief History of
Translational Neuroscience 1 Edgar Garcia-Rill Some recent history 1
Funding translational research 3 Lack of funding 4 Making NIH funding more
equitable and efficient 6 How much funding is needed? 7 Medical research
funding in Europe 10 References 13 2 Mentoring in Translational
Neuroscience 15 Edgar Garcia-Rill T1 blocks 15 T2 blocks 20 References 27 3
Core Facilities for Translational Neuroscience 29 Edgar Garcia-Rill
Designing translational neuroscience core facilities 31 Preattentional
measure--the P50 potential 33 Attentional measures--psychomotor vigilance
35 Frontal lobe blood flow measures 36 References 42 4 Translational
Studies Using TMS 43 Mark Mennemeier, Christine Sheffer, Abdallah Hayar,
and Roger Buchanan Overview 43 Introduction 44 Development of a sham
stimulation technique for humans 45 PET-guided TMS studies of tinnitus
perception 46 TMS investigations of decision-making in tobacco addiction 50
TMS investigations in rodents 54 Conclusion 61 References 61 5
Translational Studies in Drug Abuse 67 Veronica Bisagno, William E.
Fantegrossi, and Francisco J. Urbano Background and significance 67
Behavioral Core Facility 70 Voltage-sensitive dye imaging 75 Intravenous
drug self-administration 75 References 79 6 Electrophysiology in
Translational Neuroscience 83 Edgar Garcia-Rill In vivo and in vitro animal
models 83 Modafinil 84 Patch clamp recordings 85 Gamma band activity 86
Population responses 88 Preconscious awareness 89 Magnetoencephalography,
the Cadillac of human electrophysiology 91 References 94 7 Translational
Research on Spinal Cord Injury 97 Charlotte Yates and Kevin Garrison
Electrophysiological approach: H-reflex frequency-dependent depression 98
Biomechanical approach: windup of the stretch reflex 100 Interventions:
passive exercise 101 Interventions: pharmacology (L-Dopa, Modafinil) 105
Conclusions 106 References 106 8 Translational Research in Neonatology 109
Richard Whit Hall Introduction 109 The need for neonatal research 110 The
building blocks: basic research 110 Pups to babies and back again: T1
Research 111 No problem can be solved unless it is first identified
112 From the bedside to the community: T2 research 113 The role of
comparative effectiveness research 116 Barriers and rewards in
translational research in neonatology 118 Opportunities for translational
research in neonatology 119 Conclusion 119 References 120 9 Telemedicine in
Translational Neuroscience 123 Amy Ballard and Richard Whit Hall History of
telemedicine 124 Enabling access to care 125 Telemedicine Core Facility 126
Neonatal intensive care 129 Emergency departments 131 Conclusion 132
References 132 10 Implications for the Future 135 Edgar Garcia-Rill
Fragmented infrastructure 135 Incompatible databases 136 The benefits of
translational research 138 The reshaping of basic science departments 139
References 142 Index 145 Color plates appear between pages 96 and 97.