Francesco Travascio

Transport Phenomena in Intervertebral Disc

Modeling Molecular Transport and Binding Interactions in the Extracellular Matrix of the Intervertebral Disc

• Broschiertes Buch

Produktbeschreibung

Low back pain represents a significant concern in the United States, with 70% of individuals experiencing symptoms at some point in their lifetime. Symptoms of low back pain have been strongly associated with degeneration of the intervertebral disc. Insufficient nutritional supply is believed to be a major mechanism for disc degeneration. Thus, understanding nutrients' transport in intervertebral disc is crucial to elucidate the etiology of disc degeneration, and to develop strategies for tissue repair, and tissue engineering. Transport phenomena in intervertebral disc are still poorly understood. This is partly due to the limited number of available experimental techniques for investigating transport properties, and the paucity of theoretical or numerical methods for predicting solute transport in the disc. In this work, new fluorescence imaging techniques were developed to experimentally determine solute transport properties in intervertebral disc. In addition, a mixture theoryfor charged hydrated soft tissues was presented as a theoretical framework for investigating on molecular transport and binding interactions in the disc.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 216
• Englisch
• ISBN-13: 9783639245042
• ISBN-10: 3639245040
• Artikelnr.: 32308254

Autorenporträt

Francesco Travascio, Ph.D., graduated in Biomedical Engineering at the University of Miami. His research activity focuses on low back pain and the etiology of intervertebral disc degeneration. He is currently working as Post Doctoral Associate at the Tissue Biomechanics Laboratory of the University of Miami.