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Acute hypertensive heart failure is a particularly severe form of acute heart failure, whose pathophysiology is dominated by excessive vasoconstriction under the influence of neuroendocrine changes. Treatment is based on the control of respiratory distress by appropriate respiratory support and of the hemodynamic state by vasodilators. There is no consensus on the use of diuretics. The objective of the study was to compare the efficacy of the combination of isosorbide dinitrate (Risordan®) plus furosemide (Lasilix®) by intravenous route versus Risordan® alone, in the pharmacological treatment of patients admitted to the emergency department for acute hypertensive heart failure. The combination of diuretics in the pharmacological treatment of acute hypertensive heart failure did not shorten the duration of oxygen therapy or the duration of hospitalization in the emergency room, compared with nitrate derivatives alone.