This study on treatment outcomes of portal hypertension in children assessed the practice of treating portal hypertension in a tertiary teaching referral hospital in Ethiopia. The current practice is basically dependent on extrapolations of findings from adult patient care. It has included a number of statistically significant presenting symptoms and etiologies of portal hypertension which have determined longer survival under care, earlier life threatening complications or loss to follow-up critically sick. The treatment modalities have also been seen to affect the recurrence of upper gastrointestinal bleeding and survival or longevity under follow-up. Moreover, it opened some research questions calling upon further studies.