Intracanal medicaments are used for root canal disinfection. Medicaments can play an important role in the preparation of the root canal for further therapies , for example in necrotic pulp and in cases of active exudation. Antibiotics are regarded as an adjunct to definitive non - surgical or surgical endodontic therapy. They are combined in a "cocktail" in an attempt to elicit a variety of effects with a single application. A combination of antibiotics, called 'triple antibiotic paste' (TAP) was introduced especially for the regeneration and revascularization protocol and the treatment of open apex teeth with necrotic pulp. This book presents a comprehensive overview of the composition, properties, manipulative variables and performance of the TAP and the advancements in its chemistry, clinical application and performance that assures a progress in endodontics.