Paolo Curatolo (ed.)

Tuberous sclerosis complex

from basic science to clinical phenotypes
Herausgeber: Curatolo, Paolo

• Gebundenes Buch

Produktbeschreibung

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes. This book correlates genetic data and basic science, covers clinical presentation, reviews the historical background and diagnostic criteria, and presents an overview of neuropathology, molecular genetics and neurobiology in order to give a better understanding of the pathogenesis of the disease. Paediatricians and child neurologists will find this book uniquely useful.

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Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Mac Keith Press
• Seitenzahl: 330
• Erscheinungstermin: 14. Dezember 2011
• Englisch
• Abmessung: 240mm x 161mm x 22mm
• Gewicht: 663g
• ISBN-13: 9781898683391
• ISBN-10: 1898683395
• Artikelnr.: 22243298

Autorenporträt

Edited by Paolo Curatolo, Università degli Studi di Roma 'Tor Vergata'

Inhaltsangabe

Index.
Foreword by H. Sarnat.
Preface
1.
2. Historical background, Paolo Curatolo
3.
4. Diagnostic criteria, Paolo Curatolo
5.
6. Neurological manifestations, Paolo Curatolo and Magda Verdecchia
7.
8. Seizures, Paolo Curatolo and Stefano Seri
9.
10. Intellectual and cognitive impairments, Patrick F. Bolton
11.
12. Autism, Michael Dowling and Paolo Curatolo
13.
14. Neuroimaging, Alessandro Bozzao, Guglielmo Manenti and Paolo Curatolo
15.
16. Positron emission tomography, Eishi Asano, Diane C. Chugani and Harry
T. Chugani
17.
18. Dermatologic and stomatologic manifestations, Sergiusz Jozwiak and
Robert Schwartz
19.
20. Ophthalmologic manifestations, Sergiusz Jozwiak
21.
22. Renal involvement, Sergiusz Jozwiak
23.
24. Cardiac and vascular involvement, Sergiusz Jozwiak
25.
26. Hepatic, lung, splenic and pancreatic involvement, Sergiusz Jozwiak
and Paolo Curatolo
27.
28. Molecular genetics, David J. Kwiatkowski, Mary Pat Reeve, Jeremy P.
Cheadle and Julian R. Sampson
29.
30. Neuropathology, Masashi Mizuguchi and Okio Hino
31.
32. Molecular neurobiology, Peter B. Crino
33.
34. Future directions, Paolo Curatolo

Rezensionen

"The previous giant of tuberous sclerosis was Manuel Gomez of the Mayo Clinic. The present giant is surely Paolo Curatolo. Others will surely stand on his shoulders, some of whom may have their enthusiasm first lit by reading this book. Pediatric neurologists, make sure you have it." Journal of Pediatric Neurology