Tumor Models in Cancer Research

Herausgegeben:Teicher, Beverly A.

• Gebundenes Buch

Produktbeschreibung

Since the first edition of this book there has been great progress in the development of genetically engineered mouse (GEM) models of cancer. This revised and updated edition comprehensively describes the state-of-the-art in animal tumor model research.

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Beverly A. Teicher and a panel of leading experts comprehensively describe the state-of-the-art in animal tumor model research. This volume updates and extends the comprehensive presentations in the first edition. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, and genetically engineered mouse models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research 2nd edition, provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Produktdetails

• Cancer Drug Discovery and Development
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 12613458, 978-1-60761-967-3
• 2nd ed
• Seitenzahl: 708
• Erscheinungstermin: 2. Dezember 2010
• Englisch
• Abmessung: 241mm x 160mm x 41mm
• Gewicht: 1293g
• ISBN-13: 9781607619673
• ISBN-10: 1607619679
• Artikelnr.: 30686024

Autorenporträt

Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

Inhaltsangabe

TUMOR MODELS IN CANCER RESEARCH 2nd edition Beverly A Teicher Table of
Contents INTRODUCTION 1. Perspectives on the History and Evolution of Tumor
Models Shannon Decker and Edward Sausville TRANSPLANTABLE SYNGENEIC RODENT
TUMORS 2. Murine L1210 and P388 Leukemias William R Waud 3. Transplantable
Syngeneic Rodent Tumors Lisa Polin, Thomas H. Corbett, Bill J. Roberts,
Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner,
Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz 4. B16
Murine Melanomas : Historical Perspective on the Development of a Solid
Tumor Model Enrique Alvarez HUMAN TUMOR XENOGRAFTS 5. Human Tumor Xenograft
Efficacy Models Ming Liu and Daniel Hicklin 6. Imaging the Steps of
Metastasis at the Macro and Cellular Level with Fluorescent Proteins in
Real Time Robert M. Hoffman 7. Patient-derived Tumor Models and Explants
Heinz-Herbert Fiebig and Angelika M. Burger 8. The Pediatric Preclinical
Testing Program Christopher L. Morton and Peter J. Houghton 9. Imaging
Efficacy in Tumor Models Vinod Kaimal, Wilbur R. Leopold, and Patrick
McConville CARCINOGEN-INDUCED TUMORS 10. Mammary Cancer in Rats Henry J.
Thompson DISEASE AND TARGET-SPECIFIC MODELS 11. Animal Models of Melanoma
Ene T. Fairchild and William E. Carson, III 12. Experimental Animal Models
for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical
Therapeutic Approaches Gilda G. Hillman 13. Animal Models of Mesothelioma
Harvey I. Pass, Joseph B. Pincus Michele Carbone, and Magdalena Plasilova
14. The Use of Mouse Models to Study Leukemi /Lymphoma and Assess
Therapeutic Approaches William Siders 15. Spontaneous Companion Animal
(Pet) Cancers David M. Vail and Douglas H. Thamm GENETICALLY ENGINEERED
MOUSE MODELS OF CANCER 16. Genetically Engineered Mouse Models of
Pancreatic Ductal Adenocarcinoma Aram F. Hezel and Nabeel Bardeesy 17.
Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP): A Validated Model
for the Identification and Characterization of Molecular Targets and the
Evaluation of Therapeutic Agents Sharon D. Morgenbesser 18. Transgenic
Mouse Models for Cancer Prevention Research Stephen D. Hursting, Laura
Lashinger, Powel Brown, Susan N. Perkins METASTASIS MODELS 19. Models for
Evaluation of Targeted Therapies of Invasive and Metastatic Disease Suzanne
A. Eccles NORMAL TISSUE RESPONSE MODELS 20. Animal Models of Toxicities
caused by Anti-Neoplastic Therapy Stephen T. Sonis, Gregory Lyng, and
Kimberly Pouliot 21. Bone Marrow as a Critical Normal Tissue Ralph
Parchment 22. Anesthetic Considerations for the Study of Murine Tumor
Models Thies Schroeder, Siqing Shan, Mark W. Dewhirst EXPERIMENTAL METHODS
AND ENDPOINTS 23. Preclinical Tumor Response End Points Beverly A. Teicher
24. Tumor Cell Survival Sra Rockwell 25. Apoptosis In Vivo L.C. Stephens,
Luka Milas, K.K. Ang, Katherine A. Mason, and Raymond E. Meyn 26.
Transparent Window Models and Intravital Miceoscopy: Imaging Gene
Expression, Physiological Function and Therapeutic Effects in Tumors Rakesh
K. Jain, Lance L. Munn, and Dai Fukumura