Hilal Arnouk

Tumor Secreted grp170 as a Cancer Vaccine

Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response

• Broschiertes Buch

Produktbeschreibung

Grp170 is a major molecular chaperone/stress protein
resident in the ER. It is distantly related in
sequence to both hsp110 and hsp70 families. Although
most chaperones are intracellular proteins they can
be modified into secretory proteins. Chaperones
secreted into the tumor microenvironment can recruit
professional APCs and promote antigen presentation
and priming of T-lymphocytes. This book describes an
approach to target grp170 to the tumor
microenvironment, which results in tumor rejection
mediated by an adaptive immune response that is CD8+
dependent and accompanied by an enhanced cellular
immune response against a tumor-specific antigen.
Furthermore, the secreted grp170 is shown to deliver
full-length tumor antigens to the tumor
microenvironment. This approach has the potential
of being exploited clinically as a cancer-specific
vaccine in tumors of various histological origins.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 92
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783639159240
• ISBN-10: 3639159241
• Artikelnr.: 26433079

Autorenporträt

Hilal Arnouk, MD. PhD. has graduated from Roswell Park Cancer
Institute and is currently a senior postdoctoral fellow at the
University of Alabama at Birmingham. Research interests include
tumor immunotherapy, proteomics and biomarker discovery. This
book is based on thesis work completed at the University of New
York at Buffalo.