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High Quality Content by WIKIPEDIA articles! The Twelve Nidanas (Pali/Sanskrit nidana "cause, foundation, source or origin") are the best-known application of the Buddhist concept of Pratityasamutpada dependent origination), identifying the origins of suffering to be in craving and ignorance. The Twelve Nidanas are employed in the analysis of phenomena according to the principle of Pratityasamutpada . The aim of the Twelve Nidanas analysis is to reveal the origins of phenomena, and the feedback loop of conditioning and causation that leads to suffering in current and future lives.