Prashant B Shambharkar

Two to Tango - Phosphorylation and Ubiquitination in IKK activation

Mechanism of IKK (Inhibitor of Kappa B Kinase) complex activation by inducible Phosphorylation and Ubiquitination in T Cell Receptor pathway

• Broschiertes Buch

Produktbeschreibung

Nuclear Factor kappa B (NF- B) is a major
transcription factor that controls the survival
and functioning of cells. Deregulated
NF- B is associated with auto-immune
disorders and Cancer. NF- B in T cells decides the
fate of an immune reaction. NF- B is turned on by T
cell receptor (TCR) activation by a signaling
cascade that involves CARMA1-BCL10-MALT1 (CBM) and
Inhibitor of kappa B kinase (IKK) complex. TCR
inducibly phosphorylates and ubiquitinates IKK
complex to activate NF- B. However, the molecular
mechanism of IKK complex activation and the
events that interconnect CBM and IKK
complexes are not well understood. This study
evaluates the roles and requirements of IKK
phosphorylation and ubiquitination. This study finds
that the phosphorylation of IKK is mediated by PKC-
TAK1 complex and ubiquitination is mediated by CBM
complex independently. Thus, phosphorylation and
ubiquitination of the IKK complex are controlled by
two distinct signaling pathways. This study proposes
a working model for TCR induced NF- B activation,
which depicts that the CBM complex regulates IKK
ubiquitination, whereas PKC-TAK1 regulates IKK
phosphorylation.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 140
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783639158168
• ISBN-10: 3639158164
• Artikelnr.: 26484884

Autorenporträt

Dr. Prashant Shambharkar is currently a Presidential
Postdoctoral Fellow at Novartis Institute for Biomedical
Research,working on auto-immune disorders and Cancer. He
received his Ph.D in Microbiology & Immunology from SUNY at
Buffalo in 2007. He has a B.S in Microbiology from Delhi
University and a M.S in Biotechnology from MKU, Madurai.