Preface This book is the result of the study of typhoid fever in a South African in-patient population. Typhoid fever caused by Salmonella typhi remains an important public health problem of many tropical and sub-tropical countries, including South Africa where a statistically significant proportion of population lacks pure water supply and proper sanitation facilities. It is a multi-system septic febrile illness where the portal of entry of the causative organism is the gastrointestinal tract. The literature on typhoid fever is voluminous and expanding. However, still there are some important issues that have not been discussed adequately in previously published works. The methodologies used to address those issues and findings of various studies are laid out in Chapters 2 through 9. Chapter 1 provides a broad overview of typhoid fever. All tables and figure are listed chronologically according to the chapter where each is located. Mohammad EH Khan Dammam, 2015