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CVD is a major public health problem in India, often impacting the most productive years of an individual's life. The epidemiological transition plays out differently in different regions of India because of varied economic development. Taking control of the CVD epidemic in India needs all the stakeholders, including the policy makers, to acknowledge and address the social determinants that are strongly linked to CVD risk factors and to the related morbidity and mortality. The rising CVD burden and the damaging consequences it has on individuals, families, and populations require urgent attention. Creating an awareness among patients and doctors alike is the only solution.