SURESH RATTAN

Understanding and Modulating Aging, Volume 1067

Herausgeber: Rattan, Suresh I S; Clark, Brian F C; Kristensen, Peter

• Broschiertes Buch

Produktbeschreibung

For the last 40 years, biogerontology--the study of the biological basis of aging--has progressed tremendously, and it has now become an independent and respected field of study and research. This volume brings together contributions by biogerontologists, bioethicists, biodemographers, researchers, students, clinicians, and dieticians. The main areas of discussion and presentation of new research results include (1) biological and non-biological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifespan and health-span extension; (3) physiological, cellular, and molecular aspects of aging; (4) new technologies to understand and modulate aging; (5) the latest successful approaches in the prevention and treatment of age-related diseases, and (6) aging intervention, prevention, and modulation by genes, natural and synthetic molecules, and lifestyle modifications. Accordingly, the main sections of the volume focus on the following topics: defining aging, longevity, and the diseases of aging; selected aging organs; cellular aging; molecular aging; ethics of aging intervention; genetics of aging and longevity; and aging interventions. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 528
• Erscheinungstermin: 12. Juli 2006
• Englisch
• Abmessung: 229mm x 152mm x 28mm
• Gewicht: 756g
• ISBN-13: 9781573315999
• ISBN-10: 1573315990
• Artikelnr.: 22561911

Autorenporträt

Suresh Rattan is a biogerontologist - a researcher in the field of biology of ageing, biogerontology. Peter Kristensen is the editor of Understanding and Modulating Aging, Volume 1067, published by Wiley.

Inhaltsangabe

Introduction: Suresh I.S. Rattan
Peter Kristensen
Brian F.C. Clark. 1. Aging is No Longer an Unsolved Problem in Biology. Robin Holliday. 2. Free Radical theory of Aging: an Update
and increasing the Functional Life Span. Denham Harman. 3. The Free Radical Phantasm: A Panoply of Paradoxes. Randolph M. Howes. 4. Catabolic insufficiency and Aging. Alexei Terman. 5. Methionine Sulfoxide Reductases: Relevance to Aging and Protection Against Oxidative Stress. Filipe Cabreiro
Cédric R. Picot
Bertrand Friguet
Isabelle Petropoulos. 6. Inadequate Intensity of Various Components of Total Environmental Signals Can Lead to Natural Aging. Alexander V. Khalyavkin
anatoli I Yashin. 7. Cellular Redox Regulation and Pro-Oxidant Signalling Systems: A New Perspective on the Free Radical theory of Aging. anthony W. Linnane
Hayden Eastwood. 8. Human Immunosenescence: Does it Have an infectious Component?. G. Pawelec
S. Koch
C. Franceschi
A. Wikby. 9. Aging in Mouse and Human Systems: a Comparative Study. Lloyd Demetrius. 10. Extrapolaholics anonymous: Why Demographers' Rejections of A Huge Rise in Cohort Life Expectancy This Century Are Overconfident. Aubrey D.N.J. De Grey. 11. The Value of Life and the Value of Life Extension. Steven Horrobin. 12. Oxphos Supercomplexes: Respiration and Lifespan Control in the Aging Model. Podospora anserina Frank Krause
Christian Q. Scheckhuber
Alexandra Werner
Sascha Rexroth
Nicole H. Reifschneider
Norbert A. Dencher
Heinz D. Osiewacz. 13. Unraveling Age-Dependent Variation of the Mitochondrial Proteome. Norbert A. Dencher
Sataro Goto
Nicole H. Reifschneider
Michiru Sugawa
Frank Krause. 14. Stress and Ageing in Caenorhabditis Elegans. anders Olsen
Maithili C. Vantipalli
Gordon J. Lithgow. 15. Age-Dependent Decrease in Renal Glucocorticoid Receptor Function is Reversed by Dietary Restriction in Mice. Ramesh Sharma
Debipreeta Dutta. 16. Investigation of Differentially Expressed Genes in the Ventricular Myocardium of Senescent Rats. Akira Ishihata
Yumi Katano. 17. Naive T Cells in the Elderly - Are they Still there?. Gerald Pfister
Daniela Weiskopf
Lutfan Lazuardi
Rania D. Kovaiou
Beatrix Grubeck-Loebenstein. 18. Brain Lipopigment Accumulation in Normal and Pathological Aging. Dan Riga
Sorin Riga
Florin Halalau
Francisc Schneider. 19. Aging and Orchidectomy Modulate Expression of Vegf Receptors (Flt-1 and Flk-1) on Corpus Cavernosum of the Rat. Delminda Neves
Janete Santos
Nuno Tomada
Henrique Almeida. 20. Role of angiotensin Ii and Endothelin-1 Receptors in the Aging-Related Functional Changes in Rat Cardiovascular System. Akira Ishihata
Yumi Katano. 21. Mitochondria Damage Checkpoint
Aging and Cancer. Keshav K. Singh. 22. Free Radical Production by Aminoguanidine Damages DNA. George Suji
S Sivakami. 23. Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage. Alberto Sanz
Pilar Caro
Jose Gomez Sanchez
Gustavo Barja. 24. Increased Production of H2O2 As Premature Senescence Establishes in Human Fibroblasts After a Short Sublethal Exposure to H2O2. Stephanie Zdanov
Jose Remacle
Olivier Toussaint. 25. Carf Regulates P19arf-P53-P21waf1 Senescence Pathway by Multiple Check-Points. Sunil C. Kaul
Kamrul Hasan
Renu Wadhwa. 26. Structural and Functional Differences Between Mouse Mot-1 and Mot-2 Proteins That Differ in Two Amino Acids. Custer C. Deocaris
Kazuhiko Yamasaki
Kazunari Taira
Sunil C. Kaul
Renu Wadhwa. 27. Proteasomal Oscillation During Mild Heat Shock in Aging Human Skin Fibroblasts. David Christian Kraft
Custer C. Deocaris
Suresh I.S. Rattan. 28. Apoptosis and Necrosis in Senescent Human Fibroblasts. Susumu Ohshima. 29. Aging of Murine Mesenchymal Stem Cells. Christine Fehrer
Gerhard Laschober
Günter Lepperdinger. 30. Prevention of Accelerated Cell Ageing in Werner Syndrome. Terence Davis
Michèle F. Haughton
Christopher J. Jones
David Kipling. 31. Oxidative Stress induces intralysosomal Accumulation of Alzheimer Amyloid ¿-Protein in Cultured Neuroblastoma Cells. Lin Zheng
Karin Roberg
Fredrik Jerhammar
Jan Marcusson
Alexei Terman. 32. The Genetics of Human Longevity. Miriam Capri
Stefano Salvioli
Federica Sevini
Silvana Valensin
Laura Celani
Daniela Monti
Graham Pawelec
Giovanna De Benedictis
Claudio Franceschi. 33. Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis. Giusi Irma forte
Paolo Ragonese
Giuseppe Salemi
Letizia Scola
Giuseppina Candore
Marco D'amelio
antonio Crivello
Norma Di Benedetto
Domenico Nuzzo
antonio Giacalone
Domenico Lio
Calogero Caruso. 34. Opposite Role of Pro-inflammatory Alleles in Acute Myocardial infarction and Longevity: Results of Studies Performed in the Sicilian Population. Giuseppina Candore
Carmela Rita Balistreri
Maria Paola Grimaldi
Florinda Listì
Sonya Vasto
Marco Caruso
Gregorio Caimi
Enrico Hoffmann
Giuseppina Colonna-Romano
Domenico Lio
Giuseppe Paolisso
Claudio Franceschi
Calogero Caruso. 35. Association Between +1059g/C Crp Polymorphism and Acute Myocardial infarction in a Cohort of Patients From Sicily: A Pilot Study. Carmela Rita Balistreri
Sonya Vasto
Florinda Listì
Grimaldi Maria Paola
Domenico Lio
Giuseppina Colonna-Romano
Marco Caruso
Gregorio Caimi
Enrico Hoffmann
Calogero Caruso
Giuseppina Candore. 36. Inflammation
Longevity and Cardiovascular Diseases: Role of Polymorphisms of Tlr4. Giuseppina Candore
Alessandra Aquino
Carmela Rita Balistreri
Matteo Bulati
Daniele Di Carlo
Maria Paola Grimaldi
Florinda Listì
Valentina Orlando
Sonya Vasto
Marco Caruso
Giuseppina Colonna-Romano
Domenico Lio
Calogero Caruso. 37. Frequency of Polymorphisms of Signal Peptide of Tgf-Â1 and -1082g/A Snp At the Promoter Region of Il-10 Gene in a Group of Patients with Carotid Stenosis. antonio Crivello
antonio Giacalone
Letizia Scola
Giusi Irma forte
Domenico Nuzzo
Robertina Giacconi
Catia Cipriano
Giuseppina Candore
Eugenio Mocchegiani
Giuseppina Colonna Romano
Domenico Lio
Calogero Caruso. 38. Reduced Expression Levels of the Senescence Biomarker Clusterin/Apolipoprotein J in Lymphocytes from Healthy Centenarians. Ioannis P. Trougakos
Chariklia Petropoulou
Claudio Franceschi
Efstathios S. Gonos. 39. Heat Shock Protein 70 Genes and Human Longevity. A View From Denmark. Ripudaman Singh
Steen Kølvraa
Peter Bross
Kaare Christensen
Niels Gregersen
Qihua Tan
Uffe Birk Jensen
Hans Eiberg
Suresh I. S. Rattan. 40. Possible Associations Between Successful Ageing and Polymorphic Markers in Werner Gene Region Mari Sild
Cemile Koca
Mette H. Bendixen
Henrik Frederiksen
Matt Mcgue
Steen Kølvraa
Kaare Christensen
Bjørn Nexø. 41. The Pattern of Chromosome-Specific Variations in Telomere Length in Humans Show Signs of Heritability and is Maintained Through Life. J. Graakjaer
J.A. Londono-Vallejo
K. Christensen
Steen Kølvraa. 42. Identification of Genes involved in Healthy Aging and Longevity. Jens Weibel
Morten Dræby
Peter Kristensen. 43. Prevention and Treatment of Skin Aging. Jerry L. Mccullough
Kristen M. Kelly. 44. Kinetin-induced Differentiation of Normal Human Keratinocytes Undergoing Aging in vitro. Ulrich Berge
Peter Kristensen
Suresh I.S. Rattan. 45. Epidermal and Dermal Characteristics in Skin Equivalent After Systemic and Topical Application of Skin Care ingredients: Jana Vicanova
Charbel Bouez
Sophie Lacroix
Lars Lindmark
Odile Damour. 46. Map Kinases and Heat Shock-induced Hormesis in Human Fibroblasts During Serial Passaging in vitro. Elise R. Nielsen
Yvonne E.G. Eskildsen-Helmond
Suresh I.S. Rattan. 47. The Roles of Satellite Cells and Hematopoietic Stem Cells in Impaired Regeneration of Skeletal Muscle in Old Rats. Shuichi Machida
Mitsuo Narusawa. 48. Age-Related Effects of Dexamethasone Administration in Adrenal Zona Reticularis. Henrique Almeida
Liliana Matos
Jorge Ferreira
Delminda Neves. 49. Does Chronic Glycolysis Accelerate Ageing? Could this Explain how Dietary Restriction Works?. Alan R. Hipkiss. 50. Would Carnosine or a Carnivorous Diet Help Suppress Ageing and Associated Pathologies?. Alan R. Hipkiss. 51. The Necessity of Having a Proper Dose of (-)Deprenyl (D) to Prolong the Life Spans of Rats Explains Discrepancies Among Different Studies in the Past. Kenichi Kitani
Setsuko Kanai
Kyoko Miyasaka
Maria Cristina Carrillo
Gwen O. Ivy. 52. The Processing
Lysis and Elimination of Brain Lipopigments in Rejuvenation therapies Sorin Riga
Dan Riga
Francisc Schneider
Florin Halalau. 53. Effect of Dietary Restriction on Learning and Memory Impairments and Histological Alterations of Brainstem in Senescence-Accelerated Mouse (Sam) P8 Strain Ryoya Takahashi
Yukari Komiya
Sataro Goto. 54. Curcumin's Biphasic Hormetic Response on Proteasome Activity and Heat Shock Protein Synthesis in Human Keratinocytes. Rehab E. Ali
Suresh I.S. Rattan. 55. Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly individuals and Relationship with Gstm1 Genotype. A Randomized
Placebo-Controlled
Cross-Over Study Francesco Marotta
M Weksler
Y Naito
C Yoshida
M Yoshioka
P Marandola. 56. Redox Status Impairment in Liver and Kidney of Prematurely-Senescent Mice: Effectiveness of Dts Phytotherapeutic Compound. Francesco Marotta
M Harada
Sk ono-Nita
E Minelli
P Marandola. 57. A Dietary Supplement Improves an Experimental influenza-Model in Old Mice Francesco Marotta
J Cervi
C Bater
K Masulair
E Minelli
M Harada
P Marandola. 58. Pre-incubation with the Proteasome inhibitor Mg132 Enhances Proteasome Activity Via the Nrf2 Transcription Factor in Aging Human Skin Fibroblasts David Christian Kraft
Custer C. Deocaris
Renu Wadhwa
Suresh I.S. Rattan. 59. Exercise and Hormesis: Activation of Cellular antioxidant Signaling Pathway. Li Li Ji
Maria-Carmen Gomez-Cabrera
Jose Vina. 60. Stem Cells - Potential therapy for Age-Related Diseases. Moustapha Kassem. 61. Heat Shock-induced Enhancement of Osteoblastic Differentiation of Htert Immortalized Mesenchymal Stem Cells. Rune Nørgaard
Moustapha Kassem
Suresh I.S. Rattan. 62. Selective Ppar Agonists for the Treatment of Diabetes Type 2. Jan Nehlin
John P. Mogensen
ingrid Petterson
Lone Jeppesen
Jan Fleckner
Erik M. Wulff
Per Sauerberg. 63. Alzheimers Disease Pathogenesis: Role of Aging Denham. Dennis Harman. 64. RNA Regulation in Mammals. Maciej Szymanski
Jan Barciszewski. 65. Quantum Dot-Based Protein Imaging and Functional Significance of Two Mitochondrial Chaperones in Cellular Senescence and Carcinogenesis. Zeenia Kaul
Kamaljit Kaur
Sunil C. Kaul
Renu Wadhwa. 66. Phage Displayed antibodies for the Detection of Glycated Proteasome in Aging Cells. Regina Gonzalez-Dosal
Morten Dræby Sørensen
Brian F.C. Clark
Suresh I. S. Rattan
Peter Kristensen. 67. Techniques Used in Studies of Age-Related DNA Methylation Changes. Tomasz K Wojdacz
Lise Lotte Hansen. 68. Geroprotection by Glycerol: insights to its Mechanisms and Clinical Potentials. Custer C. Deocaris
Bhupal G. Shrestha
David C. Kraft
Kazuhiko Yamasaki
Sunil C. Kaul
Kazunari Taira
Suresh I. S. Rattan
Renu Wadhwa. 69. Age-Dependent Effects of in Vitro Radiofrequency Exposure (Mobile Phone) on Cd95+ T Helper Human Lymphocytes. Miriam Capri
Stefano Salvioli
Serena Altilia
Federica Sevini
Daniel Remondini
Pietro Mesirca
Ferdinando Bersani
Daniela Monti
Claudio Franceschi. 70. Severe Acute Respiratory Syndrome and Phage Display. Morten Dræby Sørensen
Brian Sørensen
Connie Jenning Melchjorsen
Jens Weibel
Jing Wang
Chen Wie Jun
Yang Huanming
Peter Kristensen