Novel respiratory virus has been emerged at the end of 2019, the disease started in China then spread rapidly and widely all over the world result in until now over 15 million patient and over 600000 deaths. A novel virus belonged to Coronaviridae has been confirmed as the causative agent and termed SARS-CoV-2. The primary zoonotic source of the novel virus still not defined, may bat was suggested as the main reservoir. The phylogenic studies revealed that the SARS-CoV-2 is set in beta corona viruses clade, and is closer to SARS-like bat CoVs. The genomic structure and constitutional proteins displayed some mutations and variances in comparison to other related human corona viruses