Liquisolid technique is a novel and promising approach to overcome the consequence of limited bioavailability. Though many studies have been reported on the development of liquisolid compacts no reports have been made on the effect of various formulation factors on liquisolid compacts. The present research work unveils the effect of various formulation factors on the preformulation and formulation characteristics of liquisolid compacts of glipizide using response surface methodology.