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Sexual reproductive health and HIV are critical issues affecting African youth. In Uganda, just like other African countries, the Lack of comprehensive sex education, limited access to contraceptives, and cultural stigmas surrounding discussions about sex contribute to the high rates of HIV transmission and unintended pregnancies among this population. Addressing these challenges requires a multi-faceted approach that includes promoting safe sexual practices, increasing awareness about HIV prevention methods, and empowering young people to make informed decisions about their sexual health. This book provides evidence on the issues affecting the optimal use of sexual and reproductive health services as predictors for vulnerability to sexually transmitted infections, including HIV. It highlights the contribution of the religious sector in the multisectoral fight against HIV among the youth.