UV Spectroscopic Method and Method Validation of Methylphenidate - Choudhury, Tirthankar;Chaurasiya, Jay;Gupta, Ashwani
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This UV-spectrophotometric technique is quite simple, accurate, precise,reproducible, and sensitive. The UV method has been developed for quantification of Methylphenidate in tablet formulation. It involves absorbance measurement at 288 nm ( max of Methylphenidate) in Ethanol and distilled water (89:11) ratio. For the UV Spectrophotometric method, linearity was obtained in a concentration range of 1-50µg/ml for methylphenidate and with a regression value of 0.9998. Recovery was found in the range of 98-101%. The standard deviation and % RSD were found to be …mehr

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Produktbeschreibung
This UV-spectrophotometric technique is quite simple, accurate, precise,reproducible, and sensitive. The UV method has been developed for quantification of Methylphenidate in tablet formulation. It involves absorbance measurement at 288 nm ( max of Methylphenidate) in Ethanol and distilled water (89:11) ratio. For the UV Spectrophotometric method, linearity was obtained in a concentration range of 1-50µg/ml for methylphenidate and with a regression value of 0.9998. Recovery was found in the range of 98-101%. The standard deviation and % RSD were found to be < 2 %. It showed the high precision of the method, in accordance with ICH guidelines. The method has been successively applied to active pharmaceutical ingredients and was validated according to ICH guidelines. The method is highly accurate, reproducible and economical.
Autorenporträt
Tirthankar Choudhury, M. Pharm (Pharmaceutical Chemistry), PhD, F.I.C., C.C: - Author has more than 25 international journal publications and 2 granted patents. Moreover, author has more than 15 years teaching and research experience. Presently the author is working at School of Pharmacy (SOP), ITM University, Gwalior, M.P.