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The effectiveness of the vaccination programme can be measured through vaccination coverage and this has been estimated using data recorded by health structures, combined with population estimates from the National Statistics Institute of Cape Verde (INE-CV). This data is consolidated at health centre level, giving rise to statistics for evaluating service coverage. This research arose due to concerns that the coverage for each vaccine did not correspond to the parameters established by the Extended Vaccination Programme, giving rise to this study which aims to analyse vaccination coverage in a time trend, 2006 - 2010, and to compare the results of administrative data and those obtained from vaccination coverage surveys carried out in 1999, 2002, 2005, 2009 and 2011, on the island of Santiago - Cape Verde.